Molecular Separations Using Mobile Phases in their Near-Critical Retrograde Regions

该项目将在其近临界， 类似超临界模式的逆行区 层析 有证据表明， 三元体系中的现象（2种溶质在超临界 溶剂），其可用于分离非常相似的化合物。 随着公司结构的变化，离职费用迅速上升。 待分离的分子变得更加相似。 超临界 分离已经显示出能够实现 显著的分辨率，例如，聚合物之间， 仅分子量。 当用于色谱模式时， 真正惊人的结果是可能的。 这可能是一个 对许多行业产生重要影响， 作为先进的高性能材料和药物。

This project will use mobile phases in their near-critical, retrograde region in a mode similar to supercritical chromatography. There is evidence of a retrograde, cross-over phenomenon in ternary systems (2 solutes in a supercritical solvent) which can be used to separate very similar compounds. Separations cost escalate rapidly as the structure of the molecules to be separated becomes more similar. Supercritical separations have already shown an ability to achieve remarkable resolutions, as for example, between polymers by molecular weight only. When used in a chromatographic mode, truly astonishing results may be possible. This could have an important impact on a number of industries as widely separated as advanced high performance materials and pharmaceuticals.