Molecular Separations Using Mobile Phases in their Near-Critical Retrograde Regions

在近临界逆行区域使用流动相进行分子分离

• 批准号: 8908828
• 负责人: Eldred Chimowitz
• 金额: $ 23.7万
• 依托单位: University of Rochester
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-10-15 至 1993-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8908828&HistoricalAwards=false
• 关键词: Molecular; Separations; Using; Mobile; Phases

This project will use mobile phases in their near-critical, retrograde region in a mode similar to supercritical chromatography. There is evidence of a retrograde, cross-over phenomenon in ternary systems (2 solutes in a supercritical solvent) which can be used to separate very similar compounds. Separations cost escalate rapidly as the structure of the molecules to be separated becomes more similar. Supercritical separations have already shown an ability to achieve remarkable resolutions, as for example, between polymers by molecular weight only. When used in a chromatographic mode, truly astonishing results may be possible. This could have an important impact on a number of industries as widely separated as advanced high performance materials and pharmaceuticals.

该项目将在其近临界逆行区域以类似于超临界色谱的模式使用流动相。有证据表明，在三元体系（两种溶质在超临界溶剂中）中存在逆行、交叉现象，可用于分离非常相似的化合物。随着待分离分子的结构变得越来越相似，分离成本迅速上升。超临界分离已经显示出一种非凡的分离能力，例如，仅通过分子量来分离聚合物。当在色谱模式下使用时，真正惊人的结果可能是可能的。这可能会对许多行业产生重要影响，如先进高性能材料和制药等广泛分离的行业。