Hormonal Modulation of the Nervous System During Metamorphosis

变态过程中神经系统的激素调节

• 批准号: 8911174
• 负责人: Richard Levine
• 金额: $ 27.02万
• 依托单位: University of Arizona
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-09-01 至 1993-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8911174&HistoricalAwards=false
• 关键词: Hormonal; Modulation; Nervous; System; During

Insect metamorphosis is a time during which the nervous system is dramatically altered to allow the very different organism which emerges from the larva to behave in new ways appropriate to its new life situation. These pronounced changes in behavior require a striking reorganization of neuronal circuits and the properties of individual cells. Dr. Levine follows the changes in a mechanosensory reflex circuit that mediates a very different behavioral response at different life stages. Using innovative state-of-the-art techniques, he examines the mechanisms by which steroid and peptide hormones direct the formation of new synapses and modifies important cellular events which are reflected in the altered patterns of behavior. Recent findings have led to the conclusion that the adult nervous system is not rigid since adult neurons can undergo morphological changes. Dr. Levine's findings will enhance our understanding of the events underlying neuronal plasticity. Thus, his work holds promise of providing insights into how changes can occur in adult brains, especially with relationship to learning and memory and recovery of function.

昆虫变态是指神经系统发生巨大改变的时期，幼虫中出现的截然不同的有机体以适合其新生活状况的新方式表现。 这些显着的行为变化需要对神经元回路和单个细胞的特性进行显着的重组。 莱文博士追踪了机械感觉反射回路的变化，该回路在不同的生命阶段介导非常不同的行为反应。 他利用创新的最先进技术，研究了类固醇和肽激素指导新突触形成并修改重要细胞事件的机制，这些事件反映在行为模式的改变中。 最近的研究结果得出这样的结论：成人神经系统并不是刚性的，因为成人神经元可以发生形态变化。 莱文博士的发现将增强我们对神经元可塑性背后事件的理解。 因此，他的工作有望提供有关成人大脑如何发生变化的见解，特别是与学习、记忆和功能恢复的关系。