U.S.-Germany Cooperative Research: Recruitment of Neuromodulatory Neurons during Behavior

美德合作研究：行为过程中神经调节神经元的招募

• 批准号: 9726330
• 负责人: Richard Levine
• 金额: $ 0.54万
• 依托单位: University of Arizona
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-03-15 至 2001-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9726330&HistoricalAwards=false
• 关键词: U.S.; Germany; Cooperative; Research; Recruitment

This award supports Dr. John Levine and a post doctoral student from the University of Arizona in a collaboration with Hans Joachim Pfl¼ger of the Department of Neurobiology at the Free University of Berlin. The collaboration will determine the neuronal pathways through which identified octopaminergic modulatory neurons are recruited during well- characterized behaviors including crawling, walking, flight, kicking, and ekdysis. In addition the U.S. and German groups will determine how the patterns of modulatory neuron recruitment are modified to accommodate behavioral changes at metamorphosis. Modulatory neurons release substances, including biogenic amines or neuropeptides that influence the function of the central and peripheral nervous systems profoundly. Although there is much information regarding the effects of modulatory substances on target neurons or muscles, relatively little is understood about the neuronal circuits that activate the modulatory neurons. This collaboration will use two complementary and well- characterized insect model systems to investigate the mechanisms involved in recruitment of those neurons.

该奖项支持约翰·莱文博士和一名来自密歇根大学的博士后学生。 亚利桑那州与神经生物学系的Hans Joachim Pfl格尔合作 在柏林自由大学。 这项合作将确定神经通路 通过该通路，在包括爬行、行走、飞行、踢和蠕动的充分表征的行为期间募集所鉴定的章鱼胺能调节神经元。 在 此外，美国和德国的组织将决定如何调节模式， 神经元募集被修改以适应变态时的行为变化。 调节神经元释放物质，包括生物胺或神经肽， 对中枢和外周神经系统的功能有着深刻的影响。 虽然 有很多关于调节物质对靶细胞的影响的信息， 神经元或肌肉，相对较少的是了解神经元回路，激活 调节神经元 这项合作将使用两个互补的和充分表征的昆虫模型系统来研究招募机制 这些神经元。