Transition-metal complexes in the Synthesis of Highly Unsaturated, Conjugated Molecules-Studies Towards the Total Synthesis of the Histrionicotoxins

过渡金属配合物在高度不饱和共轭分子合成中的应用——对组氨酸毒素全合成的研究

• 批准号: 8912609
• 负责人: Godson Nwokogu
• 金额: $ 23.53万
• 依托单位: Hampton University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-10-01 至 1993-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8912609&HistoricalAwards=false
• 关键词: Transition; metal; complexes; Synthesis; Highly

This Research Improvement in Minority Institutions (RIMI) project will study transition - metal complexes in the synthesis of highly unsaturated and conjugated molecules. The research plan will explore more fully the use of cobalt complexes for the protection of acetylene and diyne units. Results of this phase will be applied to the synthesis of histrionicotoxins, a set of complex organic molecules. Knowledge from these experiments will provide rationales for broader studies of substituent and electronic influences on the pharmacology of histrionicotoxins which in turn will increase our understanding of neuromuscular disorders. This ambitious examination of complexation reactions for transition metals will significantly increase the research capability of a predominantly minority institution. The principal investigator has excellent synthesis training and has published in refereed journals. Faculty and students working on this project will have their skills in chemical synthesis measurably improved.

这个少数民族机构的研究改进(RIMI)项目将研究高度不饱和和共轭分子合成中的过渡金属配合物。该研究计划将更充分地探索使用钴络合物来保护乙炔和二炔装置。这一阶段的结果将应用于组氨酸毒素的合成，这是一组复杂的有机分子。这些实验的知识将为更广泛地研究取代基和电子对组氨酸毒素药理的影响提供理论基础，这反过来将增加我们对神经肌肉疾病的理解。这项对过渡金属络合反应的雄心勃勃的研究将极大地提高一个以少数人为主的机构的研究能力。这位首席研究员受过良好的综合训练，曾在相关期刊上发表论文。从事这个项目的教职员工和学生在化学合成方面的技能将得到显著提高。