Thermal Tomography using Electron Resonance (ESR) Techniques

使用电子共振 (ESR) 技术的热断层扫描

• 批准号: 8913619
• 负责人: John Chato
• 金额: $ 25万
• 依托单位: University of Illinois at Urbana-Champaign
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-09-01 至 1993-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8913619&HistoricalAwards=false
• 关键词: Thermal; Tomography; using; Electron; Resonance

A noninvasive technique for measuring the temperature field inside three-dimensional living tissue using tomographic methods based on electron spin resonance (ESR) spectroscopy of nitroxide stable free radicals will be developed. The studies will examine temperature variations likely to be encountered in experiments and in clinical applications involving hyperthermia in the mammalian body. The experiment consists of three major parts: First, detailed data on temperature dependent spectra of appropriate nitroxides will be obtained in model systems, such as solutions and blood: Second, the spectra will be reexamined in the tissues of living, anesthetized mice with the additional objective of localizing the signal to specified, small additional objective of localizing the signal to specified, small volumes. Third, preliminary work will be done on the development of tomographic applicable to this method. The most significant result of this research would be a breakthrough in noninvasive temperature measurement techniques. A major shortcoming of current hyperthermia procedures is the uncertainty of the temperature distribution in the region of the application of the thermal treatment. The primary aim is to develop an effective and reasonably economical technique for in vivo uses. Variations of the technique, however, could be developed for other uses as well. Thus, ESR based thermal tomography would become a significant new component in the art and science of heat transfer.

本文提出了一种基于电子自旋共振（ESR）光谱法测量三维活体组织内部温度场的方法。这些研究将检查在实验和涉及哺乳动物身体热疗的临床应用中可能遇到的温度变化。实验包括三个主要部分：首先，在溶液和血液等模型系统中获得适当氮氧化物的温度相关光谱的详细数据；第二，在麻醉小鼠的活体组织中重新检查光谱，目的是将信号定位到指定的小体积，小体积，小体积。第三，对适用于该方法的层析成像技术进行初步研究。这项研究最重要的成果将是无创温度测量技术的突破。当前热疗方法的一个主要缺点是热疗应用区域温度分布的不确定性。主要目的是开发一种有效且合理经济的体内应用技术。然而，该技术的变体也可以用于其他用途。因此，基于ESR的热层析成像将成为传热艺术和科学的重要新组成部分。