Intraoperative Identification of Cranial Nerves in Skull Base Surgery Using Polarization Sensitive Optical Coherence Tomography
使用偏振敏感光学相干断层扫描术中识别颅底手术中的脑神经
基本信息
- 批准号:10662675
- 负责人:
- 金额:$ 13.1万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-03-15 至 2025-02-28
- 项目状态:未结题
- 来源:
- 关键词:Acoustic NeuromaAddressAffectAnatomyAreaAwardBackBiophotonicsBlood VesselsBostonBrainCancerousClinicalCollagenComplexCranial NervesCrowdingDataDeformityElectric StimulationElectromyographyEnvironmentEquipmentEvaluationExcisionFascicleFluorescenceFocus GroupsFundingGeneral HospitalsGoalsGrowthHandHomeHospitalsImageImage-Guided SurgeryImaging DeviceImaging TechniquesImaging technologyInjuryInstitutionK-Series Research Career ProgramsLabelLaboratoriesLasersLeadLipid BilayersLocationMapsMassachusettsMeasuresMentorsMicroscopeMorbidity - disease rateMotionMultimodal ImagingNerveNerve FibersNeurosurgeonOlfactory NerveOperative Surgical ProceduresOptical Coherence TomographyOpticsOutcomePatient-Focused OutcomesPerformancePhasePostdoctoral FellowPreparationResearchResearch DesignResolutionResourcesSamplingSpecificitySpectrum AnalysisSupervisionSurfaceSurgeonSystemTechnical ExpertiseTechniquesTechnologyTestingTimeTissuesTrainingTranslational ResearchUnited States National Institutes of HealthUniversitiesVariantVertebral columnVisualizationWomanWorkcareercareer developmentcontrast enhanceddeep learningdeep learning algorithmdesignelectrical measurementexperiencefirst-in-humanhuman studyiatrogenic injuryimage guidedimage guided therapyimaging facilitiesimaging modalityimprovedinventionmedical schoolsmeningiomanerve damagenerve injuryneuroimagingneurosensoryneurosurgerynoveloptical imagingpractical applicationreal-time imagesresearch and developmentskillsskull basespine bone structuretooltumorvalidation studies
项目摘要
Project summary/abstract
Identification of cranial nerves during skull base surgery is critical to avoid iatrogenic injury. Even the
slightest damage to any one of these nerves can hugely affect patient outcomes. Despite the importance
of cranial nerve identification, preoperative imaging struggles to provide the needed information. During
the surgical procedure, electrostimulation techniques are often utilized to provide a point-based analysis
of a nerve and its functional capability, but they remain unable to picture the whole field. In fact, there is
no current clinical tool capable of mapping nerve fibers and displaying their location back to the surgeon
in real time. In this project, we propose to develop an imaging tool that can fill this obvious gap in current
technology and place it directly into the hands of skull base surgeons. This tool will be based on polarization
sensitive optical coherence tomography (OCT), an optical imaging modality that shows exquisite contrast
for myelinated nerves. Recent advances in laser technology (known as circular ranging, invented by
Mentor Dr. Vakoc) have brought OCT lasers to a point where their use is compatible with the motion
induced by standard surgical workflow. This two-aim project seeks to bring circular ranging into the
operating theater during skull base surgery and assess its capability to enhance cranial nerve visualization,
uniquely combining both surgical and technical expertise. This work will take place between two NIH-
funded P41-holding institutions: the Wellman Center for Photomedicine at Massachusetts General Hospital
(MGH), home to the Center for Biomedical OCT Research (CBORT), and Brigham and Women’s Hospital
(BWH), home of the National Center for Image-Guided Therapy (NCIGT) where the resources of the
Advanced Multi-modality Image Guided Operating suite (AMIGO), both in terms of equipment and
experience, will provide the perfect environment to conduct such a study. The candidate for this award is
Dr. Danielle J. Harper, a postdoctoral fellow at MGH and Harvard Medical School. Dr. Harper has been
well trained in the field of biophotonics. Her area of expertise is OCT and its functional extensions, including
polarization mapping and depth-resolved spectroscopy. Her long-term career goal is to reach academic
independence and lead a research group focused on intraoperative optical neuroimaging. To help her
achieve this, Dr. Harper has built a strong team to guide her in all aspects of research and career
development. Dr. Benjamin J. Vakoc at MGH/HMS, an expert in optical imaging, will serve as the primary
mentor. Neurosurgeons Dr. Alexandra J. Golby and Dr. Michael Mooney at BWH will provide mentoring,
guidance, and assistance with all clinical aspects. Dr. Lei Tian of Boston University will provide supervision
and guidance for the deep learning aspects of the project, and Dr. Tayyaba Hasan at MGH/HMS will
provide general career development advice. Supported by this team, this career development award will
give Dr. Harper the remaining skills and training she requires to make the transition to full independence.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Danielle J. Harper其他文献
Three-dimensional visualization of opacifications in the murine crystalline lens by in vivo optical coherence tomography.
通过体内光学相干断层扫描对小鼠晶状体中的混浊进行三维可视化。
- DOI:
10.1364/boe.387335 - 发表时间:
2020 - 期刊:
- 影响因子:3.4
- 作者:
Pablo Eugui;Danielle J. Harper;S. Kummer;Antonia Lichtenegger;J. Gesperger;Tanja Himmel;Marco Augustin;C. Merkle;M. Glösmann;B. Baumann - 通讯作者:
B. Baumann
POLARIZATION-SENSITIVE OPTICAL COHERENCE TOMOGRAPHY
- DOI:
10.1007/springerreference_3142 - 发表时间:
2023 - 期刊:
- 影响因子:0
- 作者:
Danielle J. Harper - 通讯作者:
Danielle J. Harper
Depth-resolved multi-contrast retinal imaging with high axial resolution / submitted by Daniella J. Harper, MPhys (Hons)
- DOI:
- 发表时间:
2019 - 期刊:
- 影响因子:0
- 作者:
Danielle J. Harper - 通讯作者:
Danielle J. Harper
Imaging Brain Pathology in Alzheimer’s Disease by Contrast-Enhanced Optical Coherence Tomography
通过对比增强光学相干断层扫描对阿尔茨海默病的脑病理学进行成像
- DOI:
10.1364/fio.2018.jtu2a.128 - 发表时间:
2018 - 期刊:
- 影响因子:0
- 作者:
B. Baumann;Antonia Lichtenegger;Pablo Eugui;Martina Muck;Marco Augustin;T. Roetzer;Danielle J. Harper;A. Woehrer;C. Hitzenberger - 通讯作者:
C. Hitzenberger
Image signal-to-noise ratio in optical coherence tomography is dependent upon axial resolution
光学相干断层扫描中的图像信噪比取决于轴向分辨率
- DOI:
10.1117/12.2616059 - 发表时间:
2021 - 期刊:
- 影响因子:2
- 作者:
Danielle J. Harper;B. Vakoc - 通讯作者:
B. Vakoc
Danielle J. Harper的其他文献
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