Development of Carbohydrate Complexing Agents

碳水化合物络合剂的开发

• 批准号: 8915872
• 负责人: Eric Anslyn
• 金额: $ 3.2万
• 依托单位: University of Texas at Austin
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-08-15 至 1991-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8915872&HistoricalAwards=false
• 关键词: Development; Carbohydrate; Complexing; Agents

This award is made as the starter grant increment of Dr. Anslyn's Postdoctoral Fellowship in Chemistry Award in support of his research at the University of Texas/Austin. The goal of the research is the design and synthesis of man-made hosts for the recognition and binding of carbohydrates in aqueous media. A glucose-6-phosphate binding host will be designed and synthesized. The design method will be based on a diamond lattice grid which allows for quick identification of possible sites for molecular binding interactions between host and guest. The host will possess an enforced cavity with molecular recognition sites that are pre-organized and similar to those used by carbohydrate sequestering enzymes.

该奖项是作为博士的启动补助金增量。 Anslyn化学博士后奖学金 他在德克萨斯大学奥斯汀分校的研究成果。的目标 本研究的目的是设计和合成人工宿主， 水介质中碳水化合物的识别和结合。 将设计葡萄糖-6-磷酸结合宿主， 合成了设计方法将基于钻石 网格，允许快速识别可能的 宿主和客体之间分子结合相互作用的位点。 宿主将拥有一个强制空腔， 识别网站是预先组织和类似的那些 被碳水化合物螯合酶所利用。