Presidential Young Investigator Award/Development of Artificial Enzymes.

总统青年研究员奖/人工酶的开发。

• 批准号: 9057208
• 负责人: Eric Anslyn
• 金额: $ 18.75万
• 依托单位: University of Texas at Austin
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-01 至 1996-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9057208&HistoricalAwards=false
• 关键词: Presidential; Young; Investigator; Award; Development

This Presidential Young Investigator Award given in the Organic and Macromolecular Chemistry Program provides support for the work ("Molecular Design" or "Molecular Engineering") of Dr. Eric V. Anslyn at the University of Texas at Austin. The research involves the design, synthesis, and utilization of molecules that accomplish a specific objective or task in a similar manner to biological molecules. Molecular recognition and molecular assembly are being used to approach problems in bioorganic and organometallic catalysis, and solid state structure design. One area of study is involved with developing molecular clefts. The interior of the cleft can be used to recognize and bind several different types of molecules. The molecules are being designed to catalytically hydrolyze amides and phosphodiesters. A second area of study involves development of templates that recognize and bind organic functional groups in organic media. These templates will be attached to organometallic catalysts in order to accomplish substrate multipoint binding and to impart specificity in the catalysis. Another focus of research is on the development of electrical conductors and ferromagnets which possess important properties desired in the semiconductor and data storage industries.

这个总统青年研究员奖是在有机和大分子化学项目中颁发的，为德克萨斯大学奥斯汀分校的Eric V. Anslyn博士的工作（“分子设计”或“分子工程”）提供支持。该研究包括设计、合成和利用分子，以类似于生物分子的方式完成特定的目标或任务。分子识别和分子组装正被用于解决生物有机和有机金属催化以及固态结构设计等问题。其中一个研究领域涉及分子裂缝的形成。裂口的内部可以用来识别和结合几种不同类型的分子。这些分子被设计用来催化水解酰胺和磷酸二酯。第二个研究领域涉及识别和结合有机介质中的有机官能团的模板的开发。这些模板将被附着在有机金属催化剂上，以完成底物多点结合，并赋予催化的特异性。研究的另一个重点是电导体和铁磁体的发展，它们具有半导体和数据存储行业所需的重要特性。