U.S.-Australia Cooperative Research: Control of Cytochrome P450 Gene Expression

美澳合作研究：细胞色素P450基因表达的控制

• 批准号: 8916568
• 负责人: John Omdahl
• 金额: --
• 依托单位: University of New Mexico School of Medicine
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-07-01 至 1991-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8916568&HistoricalAwards=false
• 关键词: U.S.; Australia; Cooperative; Research; Control

This award will support collaborative research between Dr. John L. Omdahl of the University of New Mexico and Dr. Brian May at the University of Adelaide (South Australia). The research is clearly significant in the development of our understanding of the ubiquitous biological activities of the many varieties of P450 genes. For example, some P450 genes are expressed in the liver to metabolize foreign chemicals such as drugs and others are expressed in tissues for hormone production. Specifically, these researchers propose to define the control region of the P450 gene responsible for metabolism of phenobarbital in chickens, and to isolate the P450 gene of the pig to lay the ground for future work in defining the control regions of these genes responsive to hormones. The project brings together complementary expertise in that Dr. May is well-versed in the molecular biology of these systems, and Dr. Omdahl is an expert in their biology. In addition to the scientific advances anticipated and their potential applications to toxicology, the University of Adelaide's Center of Excellence for Gene Technology will serve as a resource for understanding how such centers are organized and administered for potential application at the University of New Mexico.

该奖项将支持新墨西哥大学的John L.Omdahl博士和南澳大利亚阿德莱德大学的Brian May博士之间的合作研究。这项研究显然对我们理解P450基因的许多种类的普遍生物学活性具有重要意义。例如，一些P450基因在肝脏中表达，以代谢药物等外来化学物质，另一些基因在组织中表达，以产生激素。具体地说，这些研究人员建议定义负责苯巴比妥在鸡体内代谢的P450基因的控制区，并分离猪的P450基因，为未来确定这些基因对激素反应的控制区奠定基础。该项目汇集了互补的专业知识，因为梅博士精通这些系统的分子生物学，而奥姆达尔博士是它们的生物学专家。除了预期的科学进步及其对毒理学的潜在应用外，阿德莱德大学的基因技术卓越中心将作为一个资源，了解这些中心是如何组织和管理的，以便在新墨西哥大学进行潜在的应用。