Decoding Bacterial Epigenetic Regulation

解码细菌表观遗传调控

• 批准号: DP230101499
• 负责人: Prof Kate Seib
• 金额: $ 48.13万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230101499
• 关键词: Decoding; Bacterial; Epigenetic; Regulation

This project aims to characterise bacterial epigenetic regulation by determining the mechanism of action and impact of bacterial DNA methylation. This project expects to generate new knowledge about fundamental aspects of bacterial gene regulation, using a novel combination of cutting edge DNA and RNA sequencing, proteomic and bioinformatic approaches. The expected outcomes of this project will provide new tools to facilitate the integration of epigenomic analysis into genomic studies, exponentially increasing the volume and value of data gathered. This would provide significant future benefits to all academic, biotechnology, agricultural, veterinary and pharmaceutical applications that involve bacterial genomic analysis.

该项目旨在通过确定细菌DNA甲基化的作用机制和影响来阐明细菌表观遗传调控。该项目预计将产生有关细菌基因调控的基本方面的新知识，使用尖端DNA和RNA测序，蛋白质组学和生物信息学方法的新组合。该项目的预期成果将提供新的工具，以促进将表观基因组分析纳入基因组研究，从而成倍增加所收集数据的数量和价值。这将为涉及细菌基因组分析的所有学术、生物技术、农业、兽医和制药应用提供重大的未来利益。