Dissecting bacterial signal transduction

剖析细菌信号转导

• 批准号: DP240102465
• 负责人: Prof Tim Stinear
• 金额: $ 40.76万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240102465
• 关键词: Dissecting; bacterial; signal; transduction

Bacteria have feelings. They sense and respond to changes using proteins called two-component signalling systems (TCSS). These comprise a sensor which activates a DNA binding protein in response to specific cues (signals). Using state-of-the-art genetic techniques and a synthetic biology approach, this research aims to reveal for the first time how these complex bacterial TCSS networks interact. The outcomes will be a fundamental, new understanding of how bacteria sense and respond to environmental signals; a deep dive into how bacteria feel. This knowledge will be the basis for innovative approaches to harness bacteria in biotech such as vaccine production, biofuels, or clever therapeutic interventions to stop bacterial infections.

细菌是有感情的。它们使用称为双组分信号系统（TCSS）的蛋白质来感知和响应变化。这些包括响应特定线索（信号）激活DNA结合蛋白的传感器。利用最先进的遗传技术和合成生物学方法，这项研究旨在首次揭示这些复杂的细菌TCSS网络如何相互作用。其结果将是对细菌如何感知和响应环境信号的一个基本的新理解;深入了解细菌的感受。这些知识将成为在生物技术中利用细菌的创新方法的基础，例如疫苗生产，生物燃料或聪明的治疗干预以阻止细菌感染。