Development of Sexual Behavior: A Marsupial Model

性行为的发展：有袋动物模型

• 批准号: 8919601
• 负责人: Barbara Fadem
• 金额: $ 21.7万
• 依托单位: Rutgers, The State University of New Jersey-RBHS-New Jersey Med
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-07-15 至 1993-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8919601&HistoricalAwards=false
• 关键词: Development; Sexual; Behavior; Marsupial; Model

Sex differences in reproductive behavior in mammals are determined not only by the genes and by hormones produced in adulthood, but also by steroid hormones secreted by the gonads during prenatal and postnatal development. Although it is known that testicular androgens play an important role during perinatal development, androgens are metabolized into estrogens within CNS target cells. To determine whether an androgen or its estrogenic metabolite is the differentiating hormone is complicated since placental mammalian fetuses have systems which actually "protect' them from maternal estrogen. Thus, getting estrogen to the fetus and quantifying the amount of estrogen acting on the fetus developing in utero is extremely difficult but of critical importance. Dr. Fadem uses gray opossums as a model system to examine the role of estrogen. The newborns are born at a developmental stage equivalent to that of a 13-day fetal rat or 8-week human embryo. Hence, these marsupials are mammals in which much of the fetal development occurs outside the body of the mother, making the fetal environment accessible. Dr. Fadem will manipulate the hormonal milieu during early fetal life. Her work will help define the role that estrogen plays in the development of sexually dimorphic behaviors, morphology and physiology. These data will contribute to a better understanding of various human disorders that result from insufficient or excess hormone exposure during sexual differentiation.

哺乳动物生殖行为的性别差异 不仅由基因和体内产生的激素决定， 成年期，而且还通过性腺分泌的类固醇激素 在产前和产后的发展。 虽然已知 睾丸雄激素在围产期的发育中起着重要的作用， 在发育过程中，雄激素在CNS内代谢为雌激素 靶细胞 为了确定雄激素或雌激素 代谢物是分化激素是复杂的，因为 胎盘哺乳动物的胎儿有一个系统， 母亲的雌激素。 因此，将雌激素输送给胎儿 并量化作用于胎儿的雌激素量 在子宫内发育是非常困难的， 重要性 Fadem博士使用灰色负鼠作为模型系统， 检查雌激素的作用。 新生儿出生在 发育阶段相当于13天胎鼠的发育阶段，或 8-一周人类胚胎 因此，这些有袋动物是哺乳动物， 大部分的胎儿发育发生在体外， 母亲，使胎儿的环境容易接近。 法德姆博士 会影响胎儿早期的荷尔蒙环境 她 这项工作将有助于确定雌激素在 性二态行为、形态和 physiology. 这些数据将有助于更好地了解 各种各样的人类疾病， 在性分化过程中过度暴露激素。