A Model System for the Development of Behavior

行为发展的模型系统

• 批准号: 9309422
• 负责人: Barbara Fadem
• 金额: $ 17.65万
• 依托单位: Rutgers, The State University of New Jersey-RBHS-New Jersey Med
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-09-15 至 1998-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9309422&HistoricalAwards=false
• 关键词: Model; System; Development; Behavior

9309422 Fadem Sex differences in reproductive behavior in mammals are determined not only by the genes and by hormones produced in adulthood, but also by steroid hormones secreted by the gonads during perinatal development. Although it is known that testicular androgens play an important role during perinatal development, androgens are metabolized into estrogens within CNS target cells. Determining whether an androgen or its estrogenic metabolite is the differentiating hormone is complicated since placental mammalian fetuses have systems which actually "protect" them from maternal estrogen. Thus, getting estrogen to the fetus and quantifying the amount of estrogen acting on the fetus is extremely important yet almost impossible to achieve. Dr. Fadem has developed a marsupial model to examine the role of estrogen. The newborns are born at a developmental stage equivalent to that of a 13-day fetal rat or 8-week human embryo. Hence, much of the fetal development occurs outside the body of the mother, making the fetal environment accessible in these mammals. Dr. Fadem will manipulate the hormonal environment of the newborn marsupials. She will assess the effects of these early manipulations on reproductive and aggressive behavior, morphology and physiology in adulthood. The results from these studies will contribute to a better understanding of various human disorders that result from insufficient or excess hormone exposure during sexual differentiation. ***

小行星9309422 哺乳动物生殖行为的性别差异不仅由基因和成年期产生的激素决定，还由围产期性腺分泌的类固醇激素决定。 虽然已知睾丸雄激素在围产期发育中起重要作用，但雄激素在CNS靶细胞内代谢为雌激素。 确定雄激素或其雌激素代谢物是否是分化激素是复杂的，因为胎盘哺乳动物胎儿具有实际上“保护”它们免受母体雌激素影响的系统。 因此，将雌激素送到胎儿体内并量化作用于胎儿的雌激素的量是非常重要的，但几乎不可能实现。 Fadem博士开发了一种有袋动物模型来研究雌激素的作用。 新生儿出生时的发育阶段相当于13天的胎鼠或8周的人类胚胎。 因此，许多胎儿发育发生在母体外，使这些哺乳动物可以接近胎儿环境。 法德姆博士将控制新生有袋动物的荷尔蒙环境。 她将评估这些早期操作对成年后生殖和攻击行为、形态和生理的影响。 这些研究的结果将有助于更好地了解性分化期间激素暴露不足或过量导致的各种人类疾病。 ***