Protein Crystal Growth Technology

该奖项提供资金，用于改进用于制备用于随后的X射线衍射分析的单一蛋白质晶体的技术。该奖项将允许该领域的领先者之一对几种定义明确且广泛可用的蛋白质的晶体生长进行系统研究。这些研究的数据有望为其他希望标准化和完善自己的技术的研究人员提供极好的参考。近年来，X射线结晶学在酶和其他蛋白质的结构和功能分析中发挥了核心作用。这一领域的许多进展是由于在收集和分析衍射数据方面取得的进展；尽管在理解蛋白质晶体生长过程方面取得了一些进展，但生长足够大小和质量的晶体的困难仍然是大多数蛋白质分析中的一个重大障碍。获奖者将进行的各种研究应有助于使结构研究的这一方面更加常规化，从而有助于许多新蛋白质的分析。

This award provides funds for the improvement of techniques used in the preparation of crystals of single proteins for subsequent analysis by X-ray diffraction. The award will permit systematic studies of the growth of crystals of several well defined and widely available proteins by one of the leaders in this field. The data from these studies are expected to serve as an excellent reference for other investigators who wish to standardize and perfect their own technique. In recent years, X-ray crystallography has assumed a central role in the structural and functional analysis of enzymes and other proteins. Much of the progress in this area has been due to progress in the collection and analysis of the diffraction data; although there has been some progress in understanding the process of protein crystal growth, difficulty in growing crystals of sufficient size and quality remains a significant stumbling block in the analysis of most proteins. The kinds of studies to be undertaken by the awardee should help to make this aspect of structural studies more routine and thus to facilitate the analysis of many new proteins.