Regulation of Cellular Free Amino Acid Levels During OsmoticStress

渗透压过程中细胞游离氨基酸水平的调节

• 批准号: 8941338
• 负责人: Stephen Bishop
• 金额: $ 3.07万
• 依托单位: Iowa State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-03-15 至 1991-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8941338&HistoricalAwards=false
• 关键词: Regulation; Cellular; Free; Amino; Acid

This project continues studies on free amino acid transport and its role in osmotic regulation. Phosphorylation is being studied as a key regulatory mechanism during salt stress. The hypothesis to be tested is that the intracellular levels of the readily metabolized amino acid osmolytes appear to be controlled by accumulation behind a well regulated metabolic blockade to catabolism within the mitochondria rather than by an increased rate of synthesis or by an activation of "overproducer genes" as is seen in some bacteria. Adaptation to salt stress at the cellular level is a complicated biochemical process. Cells must regulate their internal salt concentration and this has serious implications for the regulation of cell volume. This project investigates how the levels of free amino acids are involved in this process.***//

本项目继续研究游离氨基酸的转运 及其在渗透调节中的作用。 磷酸化是 作为盐胁迫过程中的关键调节机制进行研究。 有待检验的假设是， 易代谢的氨基酸渗透压物质似乎是 通过在调节良好的代谢后的积累来控制 阻断线粒体内的catalysts，而不是通过 合成速率的增加或通过激活 “过度生产基因”，如在某些细菌中所见。 在细胞水平上对盐胁迫的适应是一种 复杂的生化过程 细胞必须调节它们的 内部盐浓度，这对 来调节细胞体积。 该项目调查 游离氨基酸的水平是如何参与其中的 process.*//