Visualising Retinal Microglia as a Window into Brain Inflammation

将视网膜小胶质细胞可视化为了解大脑炎症的窗口

• 批准号: DP230101331
• 负责人: Prof Sarah Spencer
• 金额: $ 22.59万
• 依托单位: RMIT University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230101331
• 关键词: Visualising; Retinal; Microglia; Window; into

This project aims to use the unique autofluorescence signature of immune cells, microglia, imaged in the retina, as an index of brain inflammation. This project expects to provide the fundamental knowledge to allow us to image microglia non-invasively and identify the presence of brain inflammation without needing to access the brain-proper. Expected outcomes include full characterisation of microglial autofluorescence in the retina and how it relates to brain inflammation. This should provide significant downstream benefits for the detection of inflammatory brain disease well before visible symptoms develop with substantial benefit for livestock, pets, zoo and conservation animals, as well as research knowledge.

该项目旨在利用免疫细胞的独特自身荧光特征，小胶质细胞，在视网膜成像，作为脑炎症的指标。该项目希望提供基础知识，使我们能够对小胶质细胞进行非侵入性成像，并在不需要进入大脑的情况下识别大脑炎症的存在。预期的结果包括视网膜中小胶质细胞自身荧光的完整特征及其与脑炎症的关系。这将为在明显症状出现之前检测炎症性脑疾病提供显著的下游益处，对牲畜、宠物、动物园和保护动物以及研究知识都有重大益处。