Visualising Retinal Microglia as a Window into Brain Inflammation

将视网膜小胶质细胞可视化为了解大脑炎症的窗口

• 批准号: DP230101331
• 负责人: Prof Sarah Spencer
• 金额: $ 22.59万
• 依托单位: RMIT University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230101331
• 关键词: Visualising; Retinal; Microglia; Window; into

This project aims to use the unique autofluorescence signature of immune cells, microglia, imaged in the retina, as an index of brain inflammation. This project expects to provide the fundamental knowledge to allow us to image microglia non-invasively and identify the presence of brain inflammation without needing to access the brain-proper. Expected outcomes include full characterisation of microglial autofluorescence in the retina and how it relates to brain inflammation. This should provide significant downstream benefits for the detection of inflammatory brain disease well before visible symptoms develop with substantial benefit for livestock, pets, zoo and conservation animals, as well as research knowledge.

该项目旨在使用视网膜中成像的免疫细胞，小胶质细胞的独特自动荧光特征作为脑部炎症指数。该项目期望提供基本知识，使我们可以非侵入性地对小胶质细胞进行成像，并确定脑部炎症的存在而无需访问大脑疾病。预期的结果包括对视网膜中小胶质体自荧光的完全表征及其与脑部炎症的关系。这应该为检测炎症性脑疾病的检测提供显着的下游益处，然后在可见症状发展，对牲畜，宠物，动物园和保护动物以及研究知识具有很大的益处。