Early life overfeeding - mechanisms for programming obesity and long-term immune dysfunction.

生命早期过度喂养——导致肥胖和长期免疫功能障碍的机制。

• 批准号: DP1093398
• 负责人: Prof Sarah Spencer
• 金额: $ 21.64万
• 依托单位: RMIT University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2014-01-01
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1093398
• 关键词: Early; life; overfeeding; mechanisms; programming

Early life overfeeding can lead to obesity and related changes in adulthood. With this study we will discover how overfeeding can permanently alter an animal's development so that its body weight and immune functions are dysregulated. The outcomes will facilitate appropriate design of animal experiments considering the impact of neonatal programming. They will also contribute to more efficient feeding protocols for meat production in agriculture and identify targets for risk management and for preventing and ameliorating early life overfeeding effects in humans. This investigation therefore has clear benefits to the social, economic, and health aspects of obesity and to basic science and agriculture.

生命早期的过度喂养会导致肥胖和成年后的相关变化。通过这项研究，我们将发现过度喂养如何永久性地改变动物的发育，从而使其体重和免疫功能失调。这些结果将有助于考虑到新生儿编程的影响的适当的动物实验设计。它们还将有助于制定更有效的农业肉类生产喂养方案，并确定风险管理和预防和改善人类早期过度喂养影响的目标。因此，这项研究对肥胖的社会、经济和健康方面以及基础科学和农业都有明显的好处。