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Discovery and Validation of Pharmacological Probes for Understanding Protein-Protein Interactions of Focal Adhesion Signalling in Invasive Cancer Cells

Discovery and Validation of Pharmacological Probes for Understanding Protein-Protein Interactions of Focal Adhesion Signalling in Invasive Cancer Cells
用于了解侵袭性癌细胞中局灶粘附信号传导的蛋白质-蛋白质相互作用的药理学探针的发现和验证
批准号：
180992
负责人：
Alaoui-Jamali Moulay A
金额：
$40.27万
依托单位：
Lady Davis Institute for Medical Research (Mtl)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2009
资助国家：
加拿大
项目状态：
已结题
起止时间：
2009-03-01 至 2013-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=180992&lang=en
关键词：
Cell Migration And Invasion Chemistry Focal Adhesion Kinase Focal Adhesion Signaling Preclinical And Pharmacological Studies Small Molecules

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中文摘要
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英文摘要
The capacity of primary cancer to invade neighboring tissues and distant organs (metastases) is controlled by a mechanism broadly referred to as focal adhesion signaling. This mechanism allows cancer cells to become motile and to migrate to distant sites.
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Characterization and therapeutic implication of a novel class of PKC-theta inhibitors selectively targeting undifferentiated cancer cells expressing stem cell markers
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国内基金
海外基金
SCIENCE CHINA Chemistry
Science China Chemistry
运用Linkage Chemistry合成新型聚合物缀合物和刷形共聚物
  • 批准号：
    20974058
  • 项目类别：
    面上项目
  • 资助金额：
    12.0万元
  • 批准年份：
    2009
  • 负责人：
    袁金颖
  • 依托单位：
    清华大学