Purchase of a Nuclear Magnetic Resonance Spectrometer

购买核磁共振波谱仪

• 批准号: 9001438
• 负责人: Jiri Jonas
• 金额: $ 35.63万
• 依托单位: University of Illinois at Urbana-Champaign
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-05-01 至 1991-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9001438&HistoricalAwards=false
• 关键词: Purchase; Nuclear; Magnetic; Resonance; Spectrometer

A detailed study of intra- and intermolecular interactions in more complicated structures -- DNA, polypetides and small proteins, complex natureal products, polymetallic species and enzyme mimics requires less routine 1D NMR experiments, pulse sequences for various 2D NMR experiemtns, solvent supression, and variable temperature experiments. Multinuclear high field NMRs are ideally suited for use in these more complicated structures. The results from these NMR studies are useful in areas, such as polymers, catalysis, and in biology. This award from the Chemistry Shared Instrumentation Program will help the Department of Chemsitry at the University of Illinois acquire 400 MHz NMR spectrometer. The 400 MHz NMR spectrometer will be used in research investigations in the following areas of chemistry: 1. Specificity of Isoprenoid Biosynthesis and New Methodology for Organic Synthesis 2. Synthetic and Mechanistic Studies of Transition Metal- Mediated Organic Reactions 3. Selective Oxidation Chemistry on Soluble Oxides 4. Dimensional Probes of Enzyme-Coenzyme Binding Sites - 2D NMR Techniques 5. New Coordination Modes for Thiophene Complexation 6. Selective Oxidation with Osmium (VI) and Ruthenium (VI) Organometallic Complexes 7. Synthetic Analogues of Heme Proteins 8. Need for Fluorine NMR Capability 9. Structures and Biosynthesis of Antibiotics and Marine- Dervied Compounds 10. Synthetic and Mechanistic Investigations in Organic Chemistry 11. Further Studies of the Triplex Diels-Alder Reaction 12. Synthetic Structural and Mechanistic Organic Chemistry

对更复杂结构（DNA、多肽和小蛋白质、复杂天然产物、多金属物种和酶模拟物）中分子内和分子间相互作用的详细研究需要较少的常规 1D NMR 实验、各种 2D NMR 实验的脉冲序列、溶剂抑制和可变温度实验。 多核高场核磁共振非常适合用于这些更复杂的结构。 这些 NMR 研究的结果在聚合物、催化和生物学等领域非常有用。 化学共享仪器计划的这一奖项将帮助伊利诺伊大学化学系购买 400 MHz 核磁共振波谱仪。 400 MHz NMR 波谱仪将用于以下化学领域的研究调查： 1. 类异戊二烯生物合成的特异性和有机合成新方法 2. 过渡金属介导的有机反应的合成和机理研究 3. 可溶性氧化物的选择性氧化化学 4. 酶-辅酶结合位点的三维探针 - 2D NMR 技术 5. 噻吩络合的新配位模式 6. 锇 (VI) 和钌 (VI) 有机金属络合物的选择性氧化 7. 血红素蛋白的合成类似物 8. 氟核磁共振能力的需求 9. 抗生素和海洋衍生化合物的结构和生物合成 10. 有机化学的合成和机理研究 11.进一步研究 三重 Diels-Alder 反应 12. 合成结构和机理有机化学