Purchase of a Nuclear Magnetic Resonance Spectrometer

分子内和分子间相互作用的详细研究， 更复杂的结构-- DNA，多肽和小的 蛋白质、复杂的天然产物、多金属物种和 酶模拟物需要较少的常规1D NMR实验，脉冲 用于各种2D NMR实验的序列，溶剂抑制， 和变温实验。 多核强场 NMR非常适合在这些更复杂的环境中使用。 结构. 从这些NMR研究的结果是有用的， 例如聚合物、催化和生物学领域。 化学共享仪器计划（Chemistry Shared Instruments Program） 将帮助牛津大学化学系 伊利诺伊州获得400兆赫核磁共振光谱仪。 400 MHz NMR 光谱仪将用于研究调查， 以下化学领域： 1. 类异戊二烯生物合成的特异性及新方法 for Organic Synthesis 2. 过渡金属配合物的合成及机理研究 介导的有机反应 3. 可溶性氧化物的选择氧化化学 4. 酶-辅酶结合位点的二维探针 NMR技术 5. 噻吩类化合物的新配位模式 6. 锇（VI）和钌（VI）的选择性氧化 有机金属络合物 7. 血红素蛋白的合成类似物 8. 对氟NMR能力的需求 9. 抗生素和海洋生物的结构和生物合成 衍生化合物 10.有机合成与机理研究 化学 11.三重Diels-Alder反应的进一步研究 12.合成结构与机理有机化学

A detailed study of intra- and intermolecular interactions in more complicated structures -- DNA, polypetides and small proteins, complex natureal products, polymetallic species and enzyme mimics requires less routine 1D NMR experiments, pulse sequences for various 2D NMR experiemtns, solvent supression, and variable temperature experiments. Multinuclear high field NMRs are ideally suited for use in these more complicated structures. The results from these NMR studies are useful in areas, such as polymers, catalysis, and in biology. This award from the Chemistry Shared Instrumentation Program will help the Department of Chemsitry at the University of Illinois acquire 400 MHz NMR spectrometer. The 400 MHz NMR spectrometer will be used in research investigations in the following areas of chemistry: 1. Specificity of Isoprenoid Biosynthesis and New Methodology for Organic Synthesis 2. Synthetic and Mechanistic Studies of Transition Metal- Mediated Organic Reactions 3. Selective Oxidation Chemistry on Soluble Oxides 4. Dimensional Probes of Enzyme-Coenzyme Binding Sites - 2D NMR Techniques 5. New Coordination Modes for Thiophene Complexation 6. Selective Oxidation with Osmium (VI) and Ruthenium (VI) Organometallic Complexes 7. Synthetic Analogues of Heme Proteins 8. Need for Fluorine NMR Capability 9. Structures and Biosynthesis of Antibiotics and Marine- Dervied Compounds 10. Synthetic and Mechanistic Investigations in Organic Chemistry 11. Further Studies of the Triplex Diels-Alder Reaction 12. Synthetic Structural and Mechanistic Organic Chemistry