Japan (JSPS) Postdoctoral Program: Investigation of Long- Term Nucleotide Base Substitution Rate Using Complete Mitochondrial DNA Genomes

日本（JSPS）博士后计划：使用完整线粒体 DNA 基因组研究长期核苷酸碱基取代率

• 批准号: 9001757
• 负责人: Jaxk Reeves
• 金额: $ 0.72万
• 依托单位: University of Georgia Research Foundation Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-07-01 至 1992-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9001757&HistoricalAwards=false
• 关键词: Japan; JSPS; Postdoctoral; Program; Investigation

This award will provide supplementary support to enable Dr. Jaxk Reeves of the University of Georgia to conduct collaborative research for 12 months with Dr. Masami Hasegawa of the Institute of Statistical Mathematics in Tokyo, Japan. Using the complete mitochondrial genome of several completely sequenced animal species (human, cow, mouse, frog, fruit fly), the researchers will apply statistical techniques to obtain estimates and standard errors thereof of the long-term substitution rates of the elemental DNA bases (A,C,G,T). In addition, they will obtain estimates and standard errors of the relative time-distances between various species' branchings. The approach to be used is novel in that the complete mitochondrial DNA genome of five animal species will be used; approximately 16,500 base pairs for each. This will allow the researchers to address the questions of whether the rate of specific base pair substitution has been approximately constant over the millions of years of evolutionary history, and what effect position in the sequence has on substitution rates. Dr. Hasegawa is an established leader in the application of statistics to the field of genetics, and the Institute of Statistical Mathematics should prove an ideal environment for Dr. Reeves to pursue and expand his research.

该奖项将提供补充支持，使佐治亚大学的Jaxk Reeves博士能够与日本东京统计数学研究所的Masami Hasegawa博士进行为期12个月的合作研究。使用几个完全测序的动物物种(人、牛、鼠、青蛙、果蝇)的完整线粒体基因组，研究人员将应用统计技术来获得元素DNA碱基(A、C、G、T)的长期替换率的估计及其标准误差。此外，他们还将获得不同物种分支之间的相对时间距离的估计和标准误差。将使用的方法是新颖的，因为将使用五个动物物种的完整线粒体DNA基因组；每个物种大约有16,500个碱基对。这将使研究人员能够解决以下问题：在数百万年的进化历史中，特定碱基对替换率是否大致保持不变，以及序列中的位置对替换率有什么影响。长谷川博士在将统计学应用于遗传学领域方面是一位公认的领导者，统计数学研究所应该为里夫斯博士提供一个理想的环境来继续和扩大他的研究。