New Directions in Metal-Sulfur and Metal-Oxo Chemistry (Chemistry)

本研究主要围绕两个目标展开。其中一个目标是合成和研究新型金属硫酸盐配合物，作为蛋白质中金属硫中心的模型。具体系统包括Fe(SR)4!的类似物。rubredoxins2中的1-中心- Fe4S4(SR)4！高电位铁硫蛋白中的1-中心？Fe3S4(SR))3！3fe -硫蛋白中的2-中心，以及？Ni(III)(SR)n！氢化酶的中心。另一个目标是在金属氧化物化合物作为生物学中相关金属氧化物中心的类似物以及工业上重要的金属氧化物负载催化剂领域探索新的研究方向。探索新型配体的反应化学。具体地说，将研究那些易于模拟氰菊酯、核糖核苷酸还原酶、甲烷单加氧酶和光系统II中铁或锰氧化物中心的化合物。这项研究正在进行，以期获得有关这些金属中心在自然界中的结构、光谱和反应性的基本信息。互动活动包括大量的研究生化学课程讲座，以及组织工业科学家-研究生研讨会，旨在提高研究生对化学工业就业机会的认识。该项目进一步推进了VPW计划的目标，即(1)为女性提供在工程和NSF支持的科学学科中发展职业的机会；(2)通过为在工业、政府和学术机构工作的女性科学家和工程师提供更大的知名度，鼓励女性在科学和工程领域追求职业。通过鼓励妇女参与科学，这是对国家未来科学活力的宝贵投资。

This research is centered on two objectives. One goal is focused on the synthesis and study of new types of metal-thiolate complexes as models for metal-sulfur centers in proteins. Specific systems include analogs for the ?Fe(SR)4!1- center in rubredoxins2- the ?Fe4S4(SR)4!1- center in high potential iron-sulfur proteins, the ?Fe3S4(SR))3!2- center in 3Fe-sulfur proteins, and the ?Ni(III)(SR)n! center in hydrogenases. Another goal is to explore new research directions in the area of metal-oxide compounds as analogs for relevant metal-oxide centers in biology as well as in the industrially important metal- oxide supported catalyst. The reaction chemistry of new types of ligands will be explored. Specifically, compounds that are apt to mimic the iron- or manganese-oxide centers in hemerythrin, ribonucleotide reductase, methane monooxygenase and Photosystem II will be investigated. This research is being pursued with the prospect of obtaining fundamental information about the structural, spectroscopic and reactivity properties of these metal centers in nature. The interactive activities include numerous lectures in graduate chemistry courses, and putting together an industrial scientist- graduate student seminar, directed at enhancing the graduate students' awareness of career opportunities in the chemical industry. This project furthers VPW program objectives which are (1) to provide opportunities for women to advance their careers in engineering and in the disciplines of science supported by NSF and (2) to encourage women to pursue careers in science and engineering by providing greater visibility for women scientists and engineers employed in industry, government, and academic institutions. By encouraging the participation of women in science, it is a valuable investment in the Nation's future scientific vitality.