Reactions and Stereochemistry of Organometallic Compounds Related to Asymmetric Synthesis and Catalytic Activity

该项目在无机，生物无机和 有机化学课程是新的发展 有机化合物的立体选择性合成方法 以含有过渡金属的化合物为基础的， 钨和钼。这种方法是极其重要的 因为分子的三维结构 深刻地影响其化学和生物特性。 该项目的两个目标是开发新方法 使用金属络合物进行不对称和区域选择性 合成和阐明的机制， 立体选择性反应，其是合成有用的。的 高氧化态有机金属的潜在用途 也将探讨这些应用的复合物。一个新 方法将被开发用于获得详细的结构 溶液中有机金属化合物的信息。配体 含有顺磁性金属离子， 设计和合成有机金属化合物。NMR 使用这些新的移位试剂的测量将允许详细的 反应性物质的结构（角度和距离）的描绘 有机金属物质，特别是催化中间体， 它们只存在于溶液中。

The goal of this project in the Inorganic, Bioinorganic and Organometallic Chemistry Program is the development of new methods for stereoselective synthesis of organic compounds based on compounds containing such transition metals as tungsten and molybdenum. Such methods are extremely important because the three-dimensional structure of a molecule can affect profoundly its chemical and biological properties. The two aims of the project are the development of new methods using metal complexes for asymmetric and regioselective syntheses and the elucidation of the mechanisms of stereoselective reactions which are synthetically useful. The potential utility of higher oxidation state organometallic complexes for these applications will be explored also. A new method will be developed for obtaining detailed structural information for organometallic compounds in solution. Ligands containing paramagnetic metal ions which bind to organometallics will be designed and synthesized. NMR measurements using these new shift reagents will allow detailed delineation of structure (angles and distances) of reactive organometallic species, especially catalytic intermediates, which exist only in solution.