U.S.-France Cooperative Research: Asymmetric Catalysis With Chiral Metal Centers

这个为期三年的奖项支持耶鲁大学的J.W. Faller和法国斯特拉斯堡路易斯巴斯德大学的J.A. Osborn在有机金属化学方面的美法合作研究。他们的研究目标是开发新型、高效的不对称催化剂，以控制含有杂原子和碳原子的双键分子的立体化学反应。具体来说，他们将研究酮（丙酮）和亚胺（氨化合物）加氢的催化剂。Faller博士为这次合作带来了广泛的有机合成化学计量试剂设计专业知识。这与法国集团在加氢催化剂方面的经验相辅相成。不对称催化和催化剂用于控制化合物的立体化学。这些催化剂及其试剂在无毒药物的设计中起着至关重要的作用。这项研究将促进我们对催化过程的理解，并导致新的和更有效的催化剂的开发。

This three-year award supports U.S.-France cooperative research in organometallic chemistry between J.W. Faller of Yale University and J.A. Osborn of the University Louis Pasteur in Strasbourg, France. The objective of their research is to develop novel, efficient asymmetric catalysts for controlling the stereochemistry of doubled-bonded molecules containing both a heteroatom and carbon atom. Specifically they will investigate catalysts for the hydrogenation of ketones (acetones) and imines, which are ammonia compounds. Dr. Faller brings to this collaboration extensive expertise with the design of stochiometric reagents for organic synthesis. This is complemented by the French group's experience with hydrogenation catalysts. Asymmetric catalysis and catalysts are used to control the stereochemistry of compounds. These catalysts and their reagents play an essential role in the design of non-toxic drugs and pharmaceuticals. This research will advance our understanding of the catalytical processes and result in the development of new and more efficient catalytic reagents.