Reactions and Sterochemistry of Organometallic Compounds Related to Asymmetric Synthesis and Catalytic Activity

9320668法勒·耶鲁大学约翰·W·法勒博士，耶鲁大学化学系，由无机化学、生物无机化学和金属有机化学项目资助，从事与不对称合成和催化相关的研究。利用金属络合物将开发不对称和区域选择性合成的新方法。这些将包括一种有效的化学计量试剂，用于制备基于手性钼络合物的单烯丙醇，使用手性毒药来简化不对称合成催化剂的制备，以及开发用于拆分手性金属络合物的手性亚砜。与其镜像不同的对象(例如，左手手套与右手手套相比)称为手性。许多医药和农业化学品是手性的，通常只需要两个镜像分子中的一个。由于很难获得单一的镜像，因此这种分子的生产是当代化学的一个重要目标。在这个项目中，解决“不对称合成”问题的新策略将应用于广泛的反应，并将开发这些重要分子的新的、更经济的制备方法。

9320668 Faller Yale University Dr. John W. Faller, Chemistry Department, Yale University, is supported by the Inorganic, Bioinorganic, and Organometallic Chemistry Program for studies related to asymmetric synthesis and catalysis. New methods for asymmetric and regioselective syntheses will be developed using metal complexes. These will include an efficient stoichiometric reagent for the preparation of monallylic alcohols based on a chiral Mo complex, the use of chiral poisons to simplify the preparation of catalysts for asymmetric synthesis, and the development of chiral sulfoxides for the resolution of chiral metal complexes. An object which is not the same as its mirror image (e.g. a left compared to a right handed glove) is said to be chiral. Many pharmaceutical and agricultural chemicals are chiral and often only one of the two mirror image molecules is desired. Since it is difficult to obtain a single mirror image, the production of such molecules is an important goal in contemporary chemistry. In this project new strategies toward solving the problem of "asymmetric synthesis" will be applied to a broad range of reactions and new, more economic preparations of these important molecules will be developed.