Long & Medium Term Research: The Mammalian Y Chromosome, Sex Determination and Evolution, A Marsupial Approach

中长期研究：哺乳动物Y染色体，性别决定与进化，一种有袋类动物的研究方法。该奖项是在国外卓越中心中长期研究项目下推荐的。该项目旨在使美国科学家和工程师能够在国外被证明卓越的研究机构进行长期研究。该奖项为开展联合研究以及利用国外独特或互补的设施、专业知识和实验条件提供了机会。该奖项由Linda a . Strausbaugh博士赞助，将支持康狄格洲大学Gregory K. Hampikian博士与澳大利亚维多利亚州Bundoora市拉筹伯大学Jennifer M. Graves博士进行为期12个月的博士后访问，研究“哺乳动物y染色体进化和性别决定：一种有袋动物的方法”。哺乳动物Y染色体进化的主流理论预测，唯一保守的Y基因是那些涉及性别决定、雄性特异性性状和X-Y配对的基因。有袋动物（后生目）至少在1.3亿年前从胎盘动物（真生目）中分化出来。研究人员建议从有袋动物的y特异性文库中分离出保守的基因，以详细说明哺乳动物性别决定的总体计划，并阐明性染色体的进化。有袋动物Y是这些比较研究的理想选择，因为它的小尺寸（2-3 X 1,000,000碱基）便于文库的构建，并且它缺乏X染色体配对区域简化了表征。奖励建议提供资金，酌情支付国际旅行，本地旅行，津贴，家属津贴（如果适用），以及美国本土机构250美元的固定行政津贴。

Long & Medium-Term Research: The Mammalian Y Chromosome, Sex Determination and Evolution, A Marsupial Approach This award recommendation is made under the Program for Long & Medium-Term Research at Foreign Centers of Excellence. The program seeks to enable U.S. scientists and engineers to conduct long-term research abroad at research institutions of proven excellence. Awards provide opportunities for the conduct of joint research, and the use of unique or comple- mentary facilities, expertise and experimental conditions in foreign countries. This award for a proposal sponsored by Dr. Linda A. Strausbaugh will support a 12-month postdoctoral research visit by Dr. Gregory K. Hampikian of the University of Connecticut to work with Dr. Jennifer M. Graves of La Trobe University, Bundoora, Victoria, AusPtralia, on "Mammalian Y-Chromosome Evolution and Sex Determination: A Marsupial Approach." The predominant theory of mammalian Y chromosome evolution predicts that the only Y genes conserved are those involved in sex determination, male-specific traits, and X-Y pairing. Marsupials (infraclass Metatheria) diverged from placental animals (infra class Eutheria) at least 130 million years ago. The researchers propose to isolate genes conserved between the infraclasses from a marsupial Y-specific library in order to detail the general plan of mammalian sex determination and shed light on the evolution of sex chromosomes. The marsupial Y is ideal for these comparative studies because its small size (2-3 X 1,000,000 bases) facilitates library construction and its lack of an X chromosome pairing region simplifies characteri- zation. The award recommendation provides funds to cover, as appropriate, international travel, local travel abroad, stipend, dependents' allowance if applicable, and a flat administrative allowance of $250 for the U.S. home institution.