Synthesis of Vitamin K Models

维生素 K 模型的合成

• 批准号: 9014322
• 负责人: Paul Dowd DECEASED
• 金额: $ 19.8万
• 依托单位: University of Pittsburgh
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-01 至 1993-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9014322&HistoricalAwards=false
• 关键词: Synthesis; Vitamin; Models

The Organic Dynamics program will support Professor Paul Dowd's study of "Synthesis of Vitamin K Models" in the Chemistry Department at the University of Pittsburgh. Vitamin K is required for blood clotting, where it is an essential cofactor in the complex enzymic sequence known as the blood clotting cascade. This study will explore a new experimental model for the vitamin K-dependent carboxylation reaction since in the absence of carboxylation blood clotting is inhibited. A variety of methods are being used to study the new experimental model for the vitamin K-dependent carboxylation reaction, including inter- and intramolecular condensation reactions, oxygen labelling experiments, exploration of new strong bases, and new oxygenation reactions. Model experiments will determine whether molecular oxygen triggers the carboxylation reaction by reacting with the anionic form of vitamin K hydroquinone to produce vitamin K oxide, whose formation provides the energy necessary to furnish a base sufficiently strong to effect carboxylation.

有机动力学项目将支持匹兹堡大学化学系Paul Dowd教授的“维生素K模型合成”研究。维生素K是凝血所必需的，它是被称为凝血级联的复杂酶序列中必不可少的辅助因子。本研究将探索维生素k依赖性羧化反应的新实验模型，因为在缺乏羧化的情况下血液凝固受到抑制。研究维生素k依赖性羧化反应的新实验模型采用了多种方法，包括分子间和分子内缩合反应、氧标记实验、探索新的强碱和新的氧合反应。模型实验将确定分子氧是否通过与阴离子形式的维生素K对苯二酚反应产生维生素K氧化物来触发羧基化反应，维生素K氧化物的形成提供了必要的能量，以提供足够强的碱来实现羧基化。