Synthesis of Vitamin K Models

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With this renewal award, the Organic Dynamics Program is supporting the work of Professor Dowd from the University of Pittsburgh. The focus of this research is a detailed understanding of the pathway used by vitamin K which is a cofactor for carboxylase. This system is responsible for activating the proteins for the blood-clotting cascade. The study is to include elaborating the details of how vitamin K is oxidized and whether or not dialkoxy dianions are an integral part of the pathway. An additional goal is to establish the relationship between Vitamins K and E with regard to the latter acting as an inhibitor of the Vitamin K pathway. Vitamin K is the blood-clotting vitamin. As such, it is an obligatory cofactor for a carboxylase that bears responsibility for activating the proteins of the blood-clotting cascade. Professor Dowd is to focus on the mechanistic details of the pathway followed by vitamin K when it facilitates the blood-clotting process.