Synthesis of Vitamin K Models

维生素 K 模型的合成

• 批准号: 9630993
• 负责人: Craig Wilcox
• 金额: $ 34.2万
• 依托单位: University of Pittsburgh
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-06-01 至 2000-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9630993&HistoricalAwards=false
• 关键词: Synthesis; Vitamin; Models

With this renewal award, the Organic Dynamics Program is supporting the work of Professor Dowd from the University of Pittsburgh. The focus of this research is a detailed understanding of the pathway used by vitamin K which is a cofactor for carboxylase. This system is responsible for activating the proteins for the blood-clotting cascade. The study is to include elaborating the details of how vitamin K is oxidized and whether or not dialkoxy dianions are an integral part of the pathway. An additional goal is to establish the relationship between Vitamins K and E with regard to the latter acting as an inhibitor of the Vitamin K pathway. Vitamin K is the blood-clotting vitamin. As such, it is an obligatory cofactor for a carboxylase that bears responsibility for activating the proteins of the blood-clotting cascade. Professor Dowd is to focus on the mechanistic details of the pathway followed by vitamin K when it facilitates the blood-clotting process.

有了这一续期奖，有机动力学项目将支持匹兹堡大学多德教授的工作。这项研究的重点是详细了解维生素K所使用的途径，维生素K是羧基酶的辅因子。这个系统负责激活凝血级联反应的蛋白质。这项研究将包括详细阐述维生素K是如何被氧化的，以及二烷氧基二阴离子是否是该途径的组成部分。另一个目标是确定维生素K和E之间的关系，后者作为维生素K途径的抑制剂。维生素K是一种凝血的维生素。因此，它是负责激活凝血级联蛋白的羧基酶的必备辅因子。多德教授将重点研究维生素K促进血液凝结过程时所遵循的途径的机制细节。