Synthesis of Vitamin K Models

维生素 K 模型的合成

• 批准号: 9302560
• 负责人: Paul Dowd DECEASED
• 金额: $ 30.5万
• 依托单位: University of Pittsburgh
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-06-01 至 1996-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9302560&HistoricalAwards=false
• 关键词: Synthesis; Vitamin; Models

This grant from the Organic Dynamics Program supports the continuing work of Professor Paul Dowd at the University of Pittsburgh to study a new experimental model for the vitamin K-dependent carboxylation to further unravel its essential role in the complex events of blood clotting. The oxygenation of vitamin K will be studied using isotopically labeled oxygen. This will be followed by other oxygenations and investigations of the nature of the base(s) involved and of the effects of other strong bases on activity. Intramolecular models, micelles, liposomes and environments that mimic those of the membrane locale of the vitamin K action will also be explored. %%% In this project Dr. Paul Dowd will conduct an extensive set of oxygenation studies, using labeled molecular oxygen, to unravel the complex mechanism of blood clotting in which vitamin K plays an essential role. Not only is a new experimental model used for the action of vitamin K, but also its environment is modelled to mimic the membrane locale where the vitamin is active. The influence of strong bases on vitamin K's activity is an important part of this study.

有机动力学计划的这笔赠款支持 保罗·多德教授继续在哥伦比亚大学 匹兹堡研究一种新的维生素实验模型 K依赖性羧化，以进一步阐明其在 血液凝固的复杂过程维生素K的氧化作用 将使用同位素标记的氧进行研究。这将是 其次是其他氧化和调查的性质， 所涉及的碱和其他强碱对 活动分子内模型、胶束、脂质体和 环境，模仿那些膜的场所， 还将探讨维生素K的作用。 %%% 在这个项目中，保罗·多德博士将进行一系列广泛的 氧合研究，使用标记的分子氧， 复杂的凝血机制，其中维生素K发挥作用， 必不可少的角色。不仅是一个新的实验模型用于 维生素K的作用，而且它的环境是模仿 维生素活跃的细胞膜区域。的影响 维生素K活性的强基础是其中的重要组成部分 study.