U.S.-Japan Joint Seminar: Biophysical Chemistry of Retinal Proteins/January 1992/Honolulu HI

美日联合研讨会：视网膜蛋白质生物物理化学/1992 年 1 月/夏威夷州檀香山

• 批准号: 9016622
• 负责人: Richard Mathies
• 金额: $ 1.56万
• 依托单位: University of California-Berkeley
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-04-01 至 1992-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9016622&HistoricalAwards=false
• 关键词: U.S.; Japan; Joint; Seminar; Biophysical

This award provides support for the participation of eight US scientists in a joint US-Japan seminar on "the Biophysical Chemistry of Retinal Proteins". The chemistry of retinal proteins is a rapidly emerging area of biophysics. Retinal- containing pigments are a class of intrinsic membrane proteins the mediate energy and information transduction. Much research in this area concentrates upon the molecular mechanisms of the transduction processes and recent progress on site-specific mutagenesis, sequence and structure determination and spectroscopic studies of intermediate structure and dynamics now present the real possibility of determining the molecular mechanism of these processes. Most of the main contributions to this area have been made by American and Japanese scientists, many of whom it is intended should participate in this seminar. For this reason the seminar should provide an excellent forum for formulating a more complete picture or retinal transduction. The seminar is to be held on January 12-18, 1992 at the University of Hawaii, Honolulu. The co-organizers are Professor Richard Mathies, Department of Chemistry, University of California, Berkeley and Associate Professor Toshiaki Kakitani, Department of Physics, Nagoya University, Japan. Specific topics to be discussed at the seminar include (1) retinal protein structure and genetics; (2) chromophore structure and the environment; (3) photoactivation of retinal-proteins; (4) analysis of structure and transduction mechanisms; and (5) pigment regeneration and signal transduc- tion. These topics represent the right combination of biochemistry, spectrochemistry and genetic engineering to make a real contribution to this subject area. The seminar will permit representatives from several research groups in the two countries to meet and exchange information which could lead to more extensive research collaboration.

该奖项为八名美国科学家参加美日联合举办的“视网膜蛋白质的生物物理化学”研讨会提供支持。视网膜蛋白质化学是生物物理学中一个迅速兴起的领域。视网膜色素是一类固有的膜蛋白，是能量和信息转导的中介。这一领域的研究主要集中在转导过程的分子机制、定点突变、序列和结构测定以及中间结构和动力学的光谱研究等方面的最新进展，为确定这些过程的分子机制提供了真正的可能性。这一领域的大部分主要贡献都是由美国和日本的科学家做出的，其中许多人打算参加这次研讨会。出于这个原因，研讨会应该为形成更完整的图像或视网膜转导提供一个很好的论坛。研讨会将于1992年1月12-18日在夏威夷大学火奴鲁鲁举行。联合组织者是加州大学伯克利分校化学系Richard Mathies教授和日本名古屋大学物理系副教授Toshiaki Kakitani。研讨会将讨论的具体议题包括：(1)视网膜蛋白质结构和遗传学；(2)生色团结构和环境；(3)视网膜蛋白质的光激活；(4)结构和转导机制的分析；(5)色素再生和信号转导。这些主题代表了生物化学、光谱化学和遗传工程的正确组合，为这一学科领域做出了真正的贡献。研讨会将允许两国几个研究小组的代表见面并交流信息，这可能导致更广泛的研究合作。