Resonance Raman Studies of Excited-State Structure and Dynamics

激发态结构和动力学的共振拉曼研究

• 批准号: 9801651
• 负责人: Richard Mathies
• 金额: $ 13.13万
• 依托单位: University of California-Berkeley
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-15 至 2001-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9801651&HistoricalAwards=false
• 关键词: Resonance; Raman; Studies; Excited; State

In this project supported by the Experimental Physical Chemistry Program of the Chemistry Division and the Molecular Biophysics Program of the Division of Molecular and Cellular Biology, Mathies will continue time resolved Raman studies of biomolecules. Specifically he proposes (I) resonance Raman spectroscopic studies of the structure and dynamics of the 'solvated electron'; (II) time-resolved resonance Raman spectroscopic studies of chromophore dynamics in rhodopsin, bacteriorhodopsin and phytochrome using femtosecond Raman gain spectroscopy (FRGS); and (III) time resolved (ns, ps) UV resonance Raman spectroscopic studies of protein dynamics in rhodopsin, bacteriorhodopsin and phytochrome by monitoring the Trp and Try residues after photolysis. These investigations probe the basics of the interaction between light and photo-biologically active materials and will contribute to our understanding of the fundamental processes which take place in animate and inanimate living systems. The overall goal of this research is to find general principles about how chemical reactions occur in condensed phase photochemical systems at room temperature.

在化学学部实验物理化学项目和分子与细胞生物学学部分子生物物理项目的支持下，Mathies将继续进行生物分子的时间分辨拉曼研究。他特别提出(1)“溶剂化电子”的结构和动力学的共振拉曼光谱研究；（II）利用飞秒拉曼增益光谱（FRGS）研究视紫红质、细菌视紫红质和光敏色素的发色团动力学；（III）时间分辨（ns, ps）紫外共振拉曼光谱研究视紫红质、细菌视紫红质和光敏色素在光解后的Trp和Try残基。这些研究探索了光和光生物活性材料之间相互作用的基础，并将有助于我们理解发生在有生命和无生命生命系统中的基本过程。本研究的总体目标是找到在室温下凝聚态光化学系统中化学反应发生的一般原理。