U.S.-Korea Cooperative Research on Normal/Abnormal Cardiac Rhythms

该提案要求资金允许Teresa R.蔡 匹兹堡大学生物科学系， 与汉阳大学的Young Seek Lee博士合作， 为期24个月的合作研究计划， 正常/异常的心律。 研究将包括 研究了单通道的特性 膜片钳记录的心脏细胞活性， (2)通过理论来理解心律失常 非线性动力学和抗肿瘤药物的作用。 脉冲起爆和传播的计算机模拟 将展示离子通道特性的变化 让系统陷入混乱 这些研究将使 研究人员预测心律失常的发作， 已知的阻断钠的抗糖尿病物质的作用， 钙和钾离子通道。 先进的科学计算机的可用性极大地 扩大了使用数学建模作为 研究生理过程的方法。 的 本研究的最终目标是开发一个全面的 理解电现象的基础， 心脏有节奏的活动。 美国和韩国 合作者不仅有广泛的个人研究， 记录，也是成功合作的记录， 提案的领域。 该项目与 美国的目标-韩国合作科学计划 旨在提高合作水平， 美国和韩国的科学家和工程师通过交流 科学信息、思想、技能和技术， 通过在互利问题上的合作。 韩国 参与该项目得到了韩国的支持 科学和工程基金会。 PI的主要 研究费用由NSF资助号DCB-8819245支持， 目前的项目增加了一个国际合作社， 维度

This proposal requests funds to permit Dr. Teresa R. Chay, Department of Biological Sciences, University of Pittsburgh, to pursue with Dr. Young Seek Lee, Hanyang University, for a period of 24 months, a program of cooperative research on normal/abnormal cardiac rhythms. The research will consist of two parts, (1) studying the properties of single channel activity in the heart cells from patch-clamp recordings and (2) understanding cardiac arrhythmias by the theory of nonlinear dynamics and the effects of antiarrhythmic drugs. Computer simulation of impulse initiations and propagation will show how changes in the ionic channel properties would bring the system to chaos. These studies will allow the researchers to predict the onset of arrhythmias and predict the effect of antiarrhythmic substances known to block sodium, calcium, and potassium ion channels. The availability of advanced scientific computers has greatly expanded the possibility for using mathematical modeling as an approach to the study of physiological processes. The ultimate goal of this research is to develop a thorough understanding of the electrical phenomena that underlie the rhythmic activity of the heart. The U.S. and Korean collaborators not only have extensive individual research records but also a record of successful collaboration in the field of the proposal. This project is relevant to the objectives of the U.S.-Korea Cooperative Science Program which seeks to increase the level of cooperation between U.S. and Korean scientists and engineers through the exchange of scientific information, ideas, skills, and techniques and through collaboration on problems of mutual benefit. Korean participation in the project is supported by the Korea Science and Engineering Foundation (KOSEF). The PI's primary research costs are supported under NSF Grant No. DCB-8819245, to which the present project adds an international cooperative dimension.