Chemoenzymatic Synthesis of Sugar Phosphates, Disaccharides,and Oligosaccharides

这一奖项是陈纳德博士化学博士后奖学金的起始拨款增量，以支持他在特拉华大学的研究。陈纳德博士的研究重点是在化学酶作用下合成糖磷酸盐、二糖和低聚糖。将为糖苷的区域和立体选择性形成开发新的策略。天然和非天然的磷酸化糖将作为靶分子、低聚糖的前体和具有新的生物学和物理化学性质的磷酸化低聚糖的一部分来制备。原则上，酶法非常适合于对受保护最少的糖进行区域和立体选择性操作。一旦建立了合成方法，将探索衍生化合物作为生物力学、诊断和治疗工具的化学。

This award is made as the starter grant increment of Dr. Chenault's Postdoctoral Fellowship in Chemistry Award in support of his research at the University of Delaware. The thrust of Dr. Chenault's research is the chemoenzymatic synthesis of sugar phosphates, disaccharides and oligosaccharides. New strategies will be developed for the regio- and stereoselective formation of glycosides. Phosphorylated sugars, both natural and unnatural, will be prepared as target molecules, as precursors to oligosaccharides, and as part of phosphorylated oligosaccharides having new biological and physicochemical properties. In principle, enzymatic methods are ideally suited to the regio- and stereoselective manipulation of minimally protected saccharides. Once the synthetic methodology is established, the chemistry of the derived compounds as biomechanistic, diagnostic and therapeutic tools will be explored.