Chemoenzymatic Synthesis of Sugar Phosphates, Disaccharides,and Oligosaccharides

该奖项是作为Chenault博士化学博士后奖学金的启动资助增量，以支持他在特拉华大学的研究。Chenault博士的研究重点是磷酸糖、双糖和低聚糖的化学酶合成。新的策略将开发区域和立体选择性形成的糖苷。天然和非天然的磷酸化糖将被制备为靶分子，作为低聚糖的前体，并作为具有新的生物和物理化学性质的磷酸化低聚糖的一部分。原则上，酶的方法是非常适合的区域和立体选择性操作的最低保护糖。一旦合成方法建立，衍生化合物的化学作为生物力学，诊断和治疗工具将被探索。

This award is made as the starter grant increment of Dr. Chenault's Postdoctoral Fellowship in Chemistry Award in support of his research at the University of Delaware. The thrust of Dr. Chenault's research is the chemoenzymatic synthesis of sugar phosphates, disaccharides and oligosaccharides. New strategies will be developed for the regio- and stereoselective formation of glycosides. Phosphorylated sugars, both natural and unnatural, will be prepared as target molecules, as precursors to oligosaccharides, and as part of phosphorylated oligosaccharides having new biological and physicochemical properties. In principle, enzymatic methods are ideally suited to the regio- and stereoselective manipulation of minimally protected saccharides. Once the synthetic methodology is established, the chemistry of the derived compounds as biomechanistic, diagnostic and therapeutic tools will be explored.