Chemoenzymatic Synthesis of Sugar Phosphates, Disaccharides,and Oligosaccharides

该奖项是作为博士的启动补助金增量。 陈纳德化学博士后研究金奖 支持他在特拉华州大学的研究。的 Chenault博士的研究重点是化学酶 糖磷酸盐、二糖和 低聚糖。 将为该区域制定新的战略， 糖苷的立体选择性形成。 磷酸化 天然和非天然的糖将被制备为目标， 分子，作为寡糖的前体，并作为 具有新的生物活性和 物理化学性质原则上，酶法是 非常适合于区域和立体选择性操作 最低限度的保护。 一旦合成人 方法学建立，衍生的化学 作为生物力学、诊断和治疗工具的化合物 将被探索。

This award is made as the starter grant increment of Dr. Chenault's Postdoctoral Fellowship in Chemistry Award in support of his research at the University of Delaware. The thrust of Dr. Chenault's research is the chemoenzymatic synthesis of sugar phosphates, disaccharides and oligosaccharides. New strategies will be developed for the regio- and stereoselective formation of glycosides. Phosphorylated sugars, both natural and unnatural, will be prepared as target molecules, as precursors to oligosaccharides, and as part of phosphorylated oligosaccharides having new biological and physicochemical properties. In principle, enzymatic methods are ideally suited to the regio- and stereoselective manipulation of minimally protected saccharides. Once the synthetic methodology is established, the chemistry of the derived compounds as biomechanistic, diagnostic and therapeutic tools will be explored.