U.S.-New Zealand Cooperative Research: Comparative Role of Pheromone Biosynthesis Activating Neuropeptide (PBAN) in Moth Species

美国-新西兰合作研究：信息素生物合成激活神经肽（PBAN）在蛾类中的比较作用

• 批准号: 9020580
• 负责人: Wendell Roelofs
• 金额: $ 0.83万
• 依托单位: Cornell Univ - State: AWDS MADE PRIOR MAY 2010
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-02-01 至 1992-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9020580&HistoricalAwards=false
• 关键词: U.S.; New; Zealand; Cooperative; Research

This award will support collaborative research between Dr. Wendell L. Roelofs of Cornell University and Dr. Stephen Foster of the New Zealand Department of Scientific and Industrial Research (DSIRO). Over the last two decades, researchers have built a knowledge-base of the biosynthetic enzyme pathways through which production of pheromone located in glands and other organs, is activated by the brain-hormone, biosynthesis activating neuropeptide (PBAN). Critical unanswered questions,however, have pervaded these studies: How did these hormonal systems and their unique biosynthetic enzymes and brain-hormonal control of pheromone production, which are species-specific, evolve? This cooperative project will focus on this research question, that is, the evolution of how PBAN effects pheromone production in several moth species. The project represents excellent collaboration between New Zealand and U.S. researchers. The New Zealand group has extensive experience and knowledge of the only moth species known in the world to exhibit the pattern of primitive to more advanced pheromone biosynthetic pathways within the same genus. The U.S. group will apply the series of techniques, which they developed, for studying the action of PBAN, and provide synthetic PBAN for the study. The research is important fundamental work in advancing basic understanding of evolution of the brain-hormone, PBAN. Also, since hormones cause chemically-based radical changes in behavior, the study has the potential for results relevant to regulating insect behavior in areas such as cardiac activity and blood sugar.

该奖项将支持康奈尔大学的Wendell L. Roelofs博士和新西兰科学与工业研究部（DSIRO）的Stephen Foster博士之间的合作研究。在过去的二十年里，研究人员已经建立了一个生物合成酶途径的知识库，通过该途径，位于腺体和其他器官的信息素的生产被大脑激素激活，生物合成激活神经肽（PBAN）。然而，这些研究中存在着一些关键的未解之谜：这些激素系统及其独特的生物合成酶和大脑激素对信息素产生的控制是如何进化的，这些都是物种特异性的？本合作项目将重点研究PBAN对几种蛾类信息素产生影响的进化过程。该项目代表了新西兰和美国研究人员之间的卓越合作。新西兰小组拥有丰富的经验和知识，是世界上唯一已知的蛾子物种，在同一属中表现出从原始到更先进的信息素生物合成途径的模式。美国研究组将把开发的系列技术应用于研究PBAN的作用，并提供用于研究的合成PBAN。该研究是推进脑激素PBAN进化基础认识的重要基础工作。此外，由于激素会引起基于化学的行为根本变化，因此该研究有可能在调节昆虫在心脏活动和血糖等领域的行为方面取得相关结果。