Cell Body Ionic Currents

神经细胞的电活动由离子通道决定 在细胞膜内发现。 的电兴奋性 单个神经细胞依赖于离子通道的类型 表示，相对和绝对密度，以及空间 离子通道在细胞不同区域的分布。 这些因素具有功能意义， 这些因素可能是神经元可塑性的原因。 的 软体动物的神经系统提供了一个重要的模型， 研究神经回路和神经元可塑性。 本研究 该项目将研究软体动物神经元用于 在神经系统中处理信息。 电生理 电压和膜片钳方法将被用来研究 膜离子通道的生物物理学，并绘制空间 离子通道在细胞不同区域的分布。 受活动调节的生物物理特性，例如 钙和钾的失活门控将被 帮助对神经元活动的时间历史进行编码。 视频荧光显微镜将用于研究空间 细胞内钙信号的模式和细胞内钙信号的性质 细胞骨架 这项研究的结果将有助于 了解神经元信息处理和 专门负责的功能个性， 神经元

Electrical activity of nerve cells is determined by ion channels found within the cell membrane. The electrical excitability of individual nerve cells depends upon the types of ion channels expressed, the relative and absolute densities, and the spatial distributions of ion channels in different regions of the cell. These factors have a functional significance and any modification to these factors could be a cause of neuronal plasticity. The molluscan nervous system provides an important model for the study of neural circuits and neuronal plasticity. This research project will investigate the mechanisms molluscan neurons use to process information in the nervous system. Electrophysiological methods of voltage and patch clamping will be utilized to study the biophysics of membrane ion channels and to map the spatial distribution of ion channels in different areas of the cell. Biophysical properties that are modulated by activity, such as the inactivation gating of calcium and potassium, will be examined to help encode the time history of neuronal activity. Video fluorescence microscopy will be used to study the spatial patterning of intracellular calcium signals and the nature of the cytoskeleton. Results of this study will contribute to the understanding of neuronal information processing and the specializations responsible for the functional individuality of neurons.