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Nano-delivery of novel inhibitors of polynucleotide kinase/phosphatase (PNKP) for tumor targeted sensitization of colorectal cancer to DNA damage.

Nano-delivery of novel inhibitors of polynucleotide kinase/phosphatase (PNKP) for tumor targeted sensitization of colorectal cancer to DNA damage.
纳米递送新型多核苷酸激酶/磷酸酶 (PNKP) 抑制剂,用于肿瘤靶向增敏结直肠癌对 DNA 损伤的作用。
批准号:
383393
负责人:
Sadat Sams M
金额:
$7.65万
依托单位:
依托单位国家:
加拿大
项目类别:
Studentship Programs
财政年份:
2017
资助国家:
加拿大
项目状态:
已结题
起止时间:
2017-10-01 至 2020-10-01

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中文摘要
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英文摘要
Colorectal cancer (CC) is the 4th most common cause of cancer-associated death worldwide. Surgery, chemotherapy (CT), and radiotherapy (RT) are the most common treatments for CC. However, these treatments are rarely curative and cause severe side effects
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Nano-delivery systmes for targeted co-delivery of topoisomerase toxin SN-38 and its novel synergistic inhibitor of DNA repair in colorectal cancer.
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