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Role of MACROD2 Loss in DNA Repair, Chromosomal Instability and Development of Colorectal Cancer: Clinical and Therapeutic Implications

Role of MACROD2 Loss in DNA Repair, Chromosomal Instability and Development of Colorectal Cancer: Clinical and Therapeutic Implications
MACROD2 缺失在 DNA 修复、染色体不稳定性和结直肠癌发展中的作用：临床和治疗意义
批准号：
nhmrc : 1079364
负责人：
A/Pr Ian Street
金额：
$51.54万
依托单位：
The Walter and Eliza Hall Institute of Medical Research
依托单位国家：
澳大利亚
项目类别：
Project Grants
财政年份：
2015
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2015-01-01 至 2017-12-31
来源：
https://researchdata.edu.au/role-macrod2-loss-therapeutic-implications/518659
关键词：
RoleMACROD2LossDNARepair

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英文摘要
The MACROD2 gene is deleted in one-third of human bowel cancers. We have discovered that MACROD2 deletion causes defective DNA repair and tumour chromosomal instability. Here, we will use novel laboratory models to show that MACROD2 loss actively promotes bowel cancer development. We will test the clinical implication of MACROD2 loss for predicting tumour therapy response and will investigate the potential of exploiting this deficiency for drug targeting.
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Multidrug Resistance Protein 1 inhibitors to sensitise cancers to chemotherapy
  • 批准号：
    nhmrc : 1136278
  • 项目类别：
    Development Grants
  • 资助金额：
    $56.81万
  • 财政年份：
    2018
  • 负责人：
    A/Pr Ian Street
  • 依托单位：
    The University of New South Wales
Multidrug Resistance Protein 1 inhibitors to sensitise cancers to chemotherapy
  • 批准号：
    nhmrc : GNT1136278
  • 项目类别：
    Development Grants
  • 资助金额：
    $84.02万
  • 财政年份：
    2018
  • 负责人：
    A/Pr Ian Street
  • 依托单位：
High-Throughput Discovery of Synergistic Drug Combinations for Metastatic Colorectal Cancer
  • 批准号：
    nhmrc : GNT1079362
  • 项目类别：
    Project Grants
  • 资助金额：
    $147.02万
  • 财政年份：
    2015
  • 负责人：
    A/Pr Ian Street
  • 依托单位：
High-Throughput Discovery of Synergistic Drug Combinations for Metastatic Colorectal Cancer
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