Role of MACROD2 Loss in DNA Repair, Chromosomal Instability and Development of Colorectal Cancer: Clinical and Therapeutic Implications

MACROD2基因在三分之一的人类肠癌中缺失。我们发现MACROD2缺失会导致DNA修复缺陷和肿瘤染色体不稳定。在这里，我们将使用新的实验室模型来证明MACROD2丢失积极地促进肠癌的发展。我们将测试MACROD2缺失对预测肿瘤治疗反应的临床意义，并将探索利用这一缺陷作为药物靶向的可能性。

The MACROD2 gene is deleted in one-third of human bowel cancers. We have discovered that MACROD2 deletion causes defective DNA repair and tumour chromosomal instability. Here, we will use novel laboratory models to show that MACROD2 loss actively promotes bowel cancer development. We will test the clinical implication of MACROD2 loss for predicting tumour therapy response and will investigate the potential of exploiting this deficiency for drug targeting.