Laser Wavelength Specific Photodissociation of Biological Molecules in Supersonic Beams

超声束中生物分子的激光波长特定光解

• 批准号: 9022610
• 负责人: David Lubman
• 金额: $ 5万
• 依托单位: Regents of the University of Michigan - Ann Arbor
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-04-15 至 1992-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9022610&HistoricalAwards=false
• 关键词: Laser; Wavelength; Specific; Photodissociation; Biological

In research supported by the Analytical and Surface Chemistry Program in the Chemistry Division, Professor Lubman and his students will study the fragmentation of ions subjected to laser photoexcitation. By adjusting the wavelength of the light, varying amounts of energy will be imparted to the molecules, thus allowing selected sets of bonds to break. The long term goal is to develop methods which will allow differential detection of similar biomolecules. %%% In research supported by the Analytical and Surface Chemistry Program in the Chemistry Division, Lubman's group will investigate the competitive kinetics of gas phase ion fragmentation permitted by near-threshold photoexcitation. In a collisionless environment, internal redistribution of absorbed energy allows selected subsets of bonds to break. While one cannot target breaking of specific bonds, it is hoped that characteristic sets of bonds can be kinetically preferred for particular excitation conditions.

在化学系分析和表面化学项目支持的研究中，卢布曼教授和他的学生将研究激光光激发下离子的碎裂。 通过调整光的波长，将向分子传递不同量的能量，从而使选定的键组断裂。 长期目标是开发能够对相似生物分子进行差异检测的方法。 %%% 在化学部分析和表面化学项目支持的研究中，Lubman 的小组将研究近阈值光激发允许的气相离子碎片的竞争动力学。 在无碰撞环境中，吸收能量的内部重新分布允许选定的键子集断裂。 虽然人们不能以破坏特定的键为目标，但希望对于特定的激发条件，可以在动力学上优先选择一组特征键。