A Biologically Responsive and Anatomically Authentic Human Nasal Model

具有生物响应性和解剖学真实性的人类鼻模型

• 批准号: DP230100721
• 负责人: Prof Yi-Chin Toh
• 金额: $ 35.34万
• 依托单位: Queensland University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-05-11 至 2026-05-10
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230100721
• 关键词: Biologically; Responsive; Anatomically; Authentic; Human

As respiratory conditions caused by pollutants and viruses become more prevalent, human nasal models to study infection/protection mechanisms and nasal drug/vaccine delivery are increasingly important. This project aims to develop a world-first human nasal model to mimic both anatomical and biological aspects of the nasal cavity and predict the distribution and deposition of fine particles and the resultant biological response from the nasal mucosa. The aim is to overcome a key fabrication challenge - to 3D print an anatomically accurate nasal construct with a porous wall on which to grow and mature functional nasal tissue that lines a nasal cavity wall. The benefit would be enabling faster development of more targeted drugs and vaccines.

随着污染物和病毒引起的呼吸系统疾病变得越来越普遍，用于研究感染/保护机制和鼻腔药物/疫苗输送的人体鼻模型变得越来越重要。该项目旨在开发世界上第一个人类鼻模型，以模拟鼻腔的解剖学和生物学方面，并预测细颗粒的分布和沉积以及鼻粘膜产生的生物反应。其目的是克服关键的制造挑战 - 3D 打印解剖学上精确的鼻结构，该结构具有多孔壁，可在其上生长并成熟排列鼻腔壁的功能性鼻组织。这样做的好处是能够更快地开发更有针对性的药物和疫苗。