A Micro-Physiological System to Mimic Human Microbiome-Organ Interactions

模拟人类微生物组与器官相互作用的微生理系统

• 批准号: DP200101658
• 负责人: Prof Yi-Chin Toh
• 金额: $ 27.38万
• 依托单位: Queensland University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-06-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200101658
• 关键词: Micro; Physiological; System; Mimic; Human

This project aims to mimic gut microbiome-organ interactions by developing a microbial-gut coculture chip, which can reversibly interface with other organs-on-chips. This is achieved through the systematic integration of highly customisable biofabrication and microfluidic technologies. This project fills a critical technological gap in the availability of an animal-alternative system to investigate microbiome-host interactions, which will greatly complement existing meta-omics approaches. The deliverables include a proof-of-concept system validated for gut-liver axis as well as the creation of new knowledge and framework to assimilate design thinking and advanced manufacturing to elevate tissue engineering into physiology engineering.

该项目旨在通过开发微生物-肠道共培养芯片来模拟肠道微生物组-器官相互作用，该芯片可以与其他芯片上器官可逆地连接。这是通过高度可定制的生物织物和微流体技术的系统集成实现的。该项目填补了动物替代系统的可用性方面的一个关键技术空白，以研究微生物组-宿主相互作用，这将极大地补充现有的元组学方法。可交付成果包括一个针对肠-肝轴验证的概念验证系统，以及创建新的知识和框架，以吸收设计思维和先进制造，将组织工程提升为生理工程。