Modular microfluidic platform for mimicking multi-organ system interactions

用于模拟多器官系统相互作用的模块化微流体平台

• 批准号: FT180100157
• 负责人: Prof Yi-Chin Toh
• 金额: $ 50.78万
• 依托单位: Queensland University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-09-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT180100157
• 关键词: Modular; microfluidic; platform; mimicking; multi

This project aims to develop a novel, modular microfluidic platform that overcomes current limitations of integrated systems in synchronising multi-tissue culture, imaging and operational complexity. Understanding multi-organ systemic crosstalk in human health and diseases demands dynamic culture systems that can mimic such interactions. This project will deliver a first-in-class platform technology and establish international and disciplinary collaborations to develop different tissue and engineering modules relevant to applications in systemic nanotoxicology, drug bioactivation and chronic diseases. This will provide the cornerstone technology to develop a new generation of disease models and therapeutics targeting interaction dysfunctions.

该项目旨在开发一种新型的模块化微流体平台，克服集成系统在同步多组织培养，成像和操作复杂性方面的局限性。了解人类健康和疾病中的多器官系统串扰需要能够模拟这种相互作用的动态培养系统。该项目将提供一流的平台技术，并建立国际和学科合作，开发与系统性纳米毒理学、药物生物活化和慢性疾病应用相关的不同组织和工程模块。这将为开发新一代疾病模型和针对相互作用功能障碍的治疗方法提供基础技术。