Presidential Young Investigator Award

总统青年研究员奖

• 批准号: 9057661
• 负责人: Regina Murphy
• 金额: $ 15万
• 依托单位: University of Wisconsin-Madison
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-11-01 至 1996-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9057661&HistoricalAwards=false
• 关键词: Presidential; Young; Investigator; Award

The Principal Investigator (PI) intends to research two specific topic areas; Bivalent Antibody - Multivalent Antigen Interactions; and, Structure and Dynamics of beta-Amyloid Protein Aggregation. For the first topic area, experimental results will be used to construct a comprehensive numerical simulation of the complex interactions between antibody and cell-surface antigen. This quantitative analysis should be useful in developing antibody-based diagnostic assays or antigen-targeted therapeutic agents, and in analyzing other receptor-ligand systems. For the second topic area, aggregation of beta-amyloid protein into fibrils and subsequent deposition in the brain is believed to initiate processes leading to abnormalities characteristic of Alzheimer's disease. Techniques developed to carry out this topic area may lead to a better understanding of how beta-amyloid protein aggregation contributes to neurodegenerative processes, and to the development of new methods to investigate protein aggregation.

主要研究者（PI）打算研究两个 特定主题领域;双价抗体-多价 抗原相互作用;以及， β-淀粉样蛋白聚集。关于第一个主题 区域，实验结果将用于构建一个 综合数值模拟 抗体和细胞表面抗原之间的相互作用。 这种定量分析应该有助于发展 基于抗体的诊断测定或抗原靶向 治疗剂，并在分析其他 受体-配体系统 对于第二个主题领域， β-淀粉样蛋白聚集成纤维， 随后在大脑中的沉积被认为 启动导致异常的过程 阿尔茨海默病的特征 技术 为开展这一主题领域而开发的技术可能会导致 更好地理解β-淀粉样蛋白 聚集有助于神经变性过程， 以及研究新方法的发展 蛋白质聚集