Design of Targeted Toxins with Enhanced Membrane Translocation

具有增强膜易位的靶向毒素的设计

• 批准号: 9912425
• 负责人: Regina Murphy
• 金额: $ 13.7万
• 依托单位: University of Wisconsin-Madison
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-12-15 至 2003-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9912425&HistoricalAwards=false
• 关键词: Design; Targeted; Toxins; Enhanced; Membrane

The objective of this project is the quantitative analysis of receptor-mediated cytotoxin trafficking dynamics in order to develop a highly selective method for treating diseases by targeted drug delivery. The project outlines a plan for quantitatively assessing the effect of targeting molecules on the transport of toxins to the interior of animal cells. This project continues the general theme of using peptides to modify cellular processing of immunotoxins. Specifically, using endocytosis to import drugs in tandem with endosomal membrane-disrupting peptides is proposed as a means for augmenting the delivery of a therapeutic to its intracellular target (e.g. ribosomes).

本项目的目标是定量分析受体介导的细胞毒素运输动力学，以开发一种高选择性的方法，通过靶向药物输送治疗疾病。 该项目概述了定量评估靶向分子对毒素运输到动物细胞内部的影响的计划。 本项目继续使用肽来修饰免疫毒素的细胞加工的一般主题。 具体地，提出使用内吞作用与内体膜破坏肽串联输入药物作为用于增强治疗剂向其细胞内靶标（例如核糖体）递送的手段。