Japan JSPS Program: "Polymeric Micelles: A New Molecular Architecture for in Vivo Drug Carriers"

日本 JSPS 项目：“聚合胶束：体内药物载体的新分子结构”

• 批准号: 9101850
• 负责人: Sung Wan Kim
• 金额: $ 0.92万
• 依托单位: University of Utah
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-06-01 至 1994-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9101850&HistoricalAwards=false
• 关键词: Japan; JSPS; Program; Polymeric; Micelles

This award will provide supplementary support to enable Dr. Glen Kwon of the University of Utah to conduct collaborative research with Dr. Teruo Okano for 16 months at the Institute of Biomedical Engineering, Tokyo Women's Medical College, in Tokyo, Japan. Kwon and Okano will apply Kwon's knowledge of polymeric microspheres and controlled delivery systems to conduct research on polymeric micelles as a drug carrier for adriamycin. Colloidal drug carriers, such as polymeric microspheres, liposomes, and soluble polymeric carriers, have been developed to increase the efficacy of drug action in vivo. The disadvantages of these systems, however, preclude their ability to increase the therapeutic index of many drugs. A new drug carrier synthesized of polymeric micelles has been developed in Japan and has proven to increase the efficiency of adriamycin without the problems associated with the other methods. Leading-edge research on polymeric micelle drug delivery systems is advancing quickly in Japan, and Okano's laboratory is one of the best. Kwon's knowledge of pharmaceutics and controlled drug delivery systems involving proteins and polypeptides complements Okano's expertise in synthesizing polymeric micelles. This collaborative research will provide Kwon with first-hand knowledge of the Japanese approach to novel polymer synthesis methods and applications of biomaterials as drug carriers.

该奖项将为犹他大学的 Glen Kwon 博士与 Teruo Okano 博士在日本东京女子医学院生物医学工程研究所进行为期 16 个月的合作研究提供补充支持。 Kwon 和 Okano 将运用 Kwon 在聚合物微球和控释系统方面的知识，对作为阿霉素药物载体的聚合物胶束进行研究。 胶体药物载体，例如聚合物微球、脂质体和可溶性聚合物载体，已被开发用于提高药物在体内作用的功效。 然而，这些系统的缺点妨碍了它们提高许多药物的治疗指数的能力。 日本开发出了一种由聚合物胶束合成的新型药物载体，并已被证明可以提高阿霉素的效率，而不会出现其他方法的相关问题。 日本关于聚合物胶束药物输送系统的前沿研究正在迅速推进，冈野的实验室是最好的实验室之一。 Kwon 在涉及蛋白质和多肽的药剂学和受控药物输送系统方面的知识补充了 Okano 在合成聚合物胶束方面的专业知识。 这项合作研究将为 Kwon 提供日本新型聚合物合成方法以及生物材料作为药物载体的应用的第一手知识。