Japan JSPS Program: "Polymeric Micelles: A New Molecular Architecture for in Vivo Drug Carriers"

该奖项将提供补充支持 让伦敦大学的格伦·权博士 犹他州进行合作研究与博士。 Teruo Okano在研究所工作了16个月 东京女子医疗大学生物医学工学部 大学，在日本东京。 权和冈野 运用Kwon的聚合物知识 微球和控释系统， 开展聚合物胶束的研究， 阿霉素的药物载体。 胶体药物载体，例如聚合物载体， 微球、脂质体和可溶性聚合物 载体，已开发，以增加 体内药物作用的功效。 的 然而，这些系统的缺点是， 排除了他们增加 许多药物的治疗指数。 一种新药 聚合物胶束合成的载体， 在日本开发，并已被证明 增加阿霉素的效率， 与其他方法相关的问题。 高分子胶束药物的前沿研究 输送系统在日本发展迅速， 冈野的实验室是最好的之一。 Kwon的药剂学知识 受控药物输送系统， 蛋白质和多肽补充冈野的 合成聚合物胶束的专业知识。 这项合作研究将为Kwon提供 对日本人有第一手的了解 新的聚合物合成方法和 生物材料作为药物载体的应用。

This award will provide supplementary support to enable Dr. Glen Kwon of the University of Utah to conduct collaborative research with Dr. Teruo Okano for 16 months at the Institute of Biomedical Engineering, Tokyo Women's Medical College, in Tokyo, Japan. Kwon and Okano will apply Kwon's knowledge of polymeric microspheres and controlled delivery systems to conduct research on polymeric micelles as a drug carrier for adriamycin. Colloidal drug carriers, such as polymeric microspheres, liposomes, and soluble polymeric carriers, have been developed to increase the efficacy of drug action in vivo. The disadvantages of these systems, however, preclude their ability to increase the therapeutic index of many drugs. A new drug carrier synthesized of polymeric micelles has been developed in Japan and has proven to increase the efficiency of adriamycin without the problems associated with the other methods. Leading-edge research on polymeric micelle drug delivery systems is advancing quickly in Japan, and Okano's laboratory is one of the best. Kwon's knowledge of pharmaceutics and controlled drug delivery systems involving proteins and polypeptides complements Okano's expertise in synthesizing polymeric micelles. This collaborative research will provide Kwon with first-hand knowledge of the Japanese approach to novel polymer synthesis methods and applications of biomaterials as drug carriers.