Microstructural Modeling of the Bone Implant Interface

这一建议是PI以前关于骨骼对机械应力的响应的理论工作的延伸。其目的是扩展数学理论，以描述骨-种植体界面上发生的变化。一种被称为边界单元法的计算程序将被用来分析骨的微结构重塑，并确定机械稳定性随时间的变化。如果这一理论被证明是正确的，这项工作将导致骨假体设计的改进。

This proposal is an extension of the PI's previous theoretical work on the response of bone to mechanical stresses. The intent is to extend the mathematical theory to describe the changes that occur at the bone-implant interface. A computational procedure known as boundary element method will be used to analyze the microstructural remodeling of bone and to determine the variation in mechanical stability as a function of time. If the theory is proven correct, the work will lead to the improved design of bone protheses.