Microstructural Modeling of the Bone Implant Interface

这一建议是PI先前理论的延伸， 研究骨骼对机械应力的反应。 意图 是扩展数学理论来描述 发生在骨-植入物界面。 一种计算程序， 称为边界元法将被用来分析 骨的微观结构重塑，并确定变化 机械稳定性随时间的变化。 如果理论是 被证明是正确的，这项工作将导致骨设计的改进。 假肢

This proposal is an extension of the PI's previous theoretical work on the response of bone to mechanical stresses. The intent is to extend the mathematical theory to describe the changes that occur at the bone-implant interface. A computational procedure known as boundary element method will be used to analyze the microstructural remodeling of bone and to determine the variation in mechanical stability as a function of time. If the theory is proven correct, the work will lead to the improved design of bone protheses.