Feeding and exciting bone cells with interstitial fluid movement

在这个项目中，PI将测量腔隙-小管骨孔隙的渗透性，并将开发一个多孔弹性模型来预测正常、循环、全身运动（例如步行）中腔隙-小管孔隙和孔径大得多的血管孔隙之间的间质液交换。一项试点研究已经探索了完成这些测量的技术。用于预测正常、循环、全身运动中腔隙-小管孔隙度和孔径大得多的血管孔隙度之间的间质液交换的多孔弹性模型的开发引入了嵌套孔隙空间结构的新概念。了解骨力传导对于了解如何治疗骨质疏松症、如何应对长期载人航天飞行中的微重力以及如何设计植入骨组织以实现更长时间功能的假体至关重要。该研究项目将涉及 CCNY 和城市理工学院的学生、CCNY 数学、科学和工程高中的学生以及理学硕士的学生。 319，玛丽亚·特蕾莎·马里巴尔学校。对骨骼健康感兴趣的纽约市专业社区将在公开的纽约市骨骼研讨会系列中及时了解研究进展。

In this project the PI will measure the permeability of the lacunar-canalicular bone porosity and will develop a poroelastic model to predict the interchange of interstitial fluid between the lacunar-canalicular porosity and the much larger pore size vascular porosity in normal, cyclic, whole body motion (e.g., walking). The techniques for accomplishing these measurements have been explored in a pilot study. The development of a poroelastic model to predict the interchange of interstitial fluid between the lacunar-canalicular porosity and the much larger pore size vascular porosity in normal, cyclic, whole body motion introduces a new concept of nested pore space structures. Understanding bone mechanotransduction is fundamental to the understanding of how to treat osteoporosis, how to cope with microgravity in long term manned space flight and how to design prostheses that are implanted in bone tissue to function for longer periods. The research project will involve CCNY and City Tech students, students at the CCNY High School for Math, Science and Engineering as well as students at M.S. 319, the Maria Teresa Maribal School. The NYC professional community interested in bone health will be kept abreast of research developments in the public NYC Bone Seminar Series.