Feeding and exciting bone cells with interstitial fluid movement

通过间质液运动喂养和刺激骨细胞

• 批准号: 0848491
• 负责人: Stephen Cowin
• 金额: $ 25万
• 依托单位: CUNY City College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0848491&HistoricalAwards=false
• 关键词: Feeding; exciting; bone; cells; interstitial

In this project the PI will measure the permeability of the lacunar-canalicular bone porosity and will develop a poroelastic model to predict the interchange of interstitial fluid between the lacunar-canalicular porosity and the much larger pore size vascular porosity in normal, cyclic, whole body motion (e.g., walking). The techniques for accomplishing these measurements have been explored in a pilot study. The development of a poroelastic model to predict the interchange of interstitial fluid between the lacunar-canalicular porosity and the much larger pore size vascular porosity in normal, cyclic, whole body motion introduces a new concept of nested pore space structures. Understanding bone mechanotransduction is fundamental to the understanding of how to treat osteoporosis, how to cope with microgravity in long term manned space flight and how to design prostheses that are implanted in bone tissue to function for longer periods. The research project will involve CCNY and City Tech students, students at the CCNY High School for Math, Science and Engineering as well as students at M.S. 319, the Maria Teresa Maribal School. The NYC professional community interested in bone health will be kept abreast of research developments in the public NYC Bone Seminar Series.

在本项目中，PI将测量腔隙-小管骨孔隙度的渗透性，并将开发一个多孔弹性模型，以预测正常、周期性全身运动中腔隙-小管孔隙度和更大孔径血管孔隙度之间的间质液交换（例如，步行）。已在一项试点研究中探讨了完成这些测量的技术。孔隙弹性模型的发展，以预测间质液之间的交换腔隙-小管孔隙度和更大的孔径血管孔隙度在正常的，循环的，全身运动介绍了一个新的概念，嵌套孔隙空间结构。了解骨机械传导对于了解如何治疗骨质疏松症，如何科普长期载人航天飞行中的微重力以及如何设计植入骨组织中以长期发挥作用的假体至关重要。该研究项目将涉及CCNY和城市技术的学生，学生在CCNY高中数学，科学和工程以及学生在MS。319号，玛丽亚·特蕾莎·玛丽巴尔学校。对骨骼健康感兴趣的纽约市专业社区将随时了解公开的纽约市骨骼研讨会系列的研究进展。