Feeding and exciting bone cells with interstitial fluid movement

在这个项目中，PI将测量腔隙骨孔隙的渗透性，并将开发一个孔弹性模型来预测腔隙骨孔隙和更大孔径的血管孔隙在正常、循环、全身运动（如行走）中间隙流体的交换。完成这些测量的技术已经在一项初步研究中进行了探索。在正常的、循环的、全身运动中，孔隙弹性模型用于预测腔隙-管状孔隙和更大孔径的维管状孔隙之间的间隙流体交换，引入了嵌套孔隙空间结构的新概念。了解骨机械转导是理解如何治疗骨质疏松症、如何应对长期载人航天飞行中的微重力以及如何设计植入骨组织的假体以长时间发挥作用的基础。该研究项目将涉及CCNY和城市理工学院的学生，CCNY数学，科学和工程高中的学生以及ms . 319， Maria Teresa Maribal学校的学生。对骨骼健康感兴趣的纽约市专业团体将在公共纽约市骨骼系列研讨会上了解最新的研究进展。

In this project the PI will measure the permeability of the lacunar-canalicular bone porosity and will develop a poroelastic model to predict the interchange of interstitial fluid between the lacunar-canalicular porosity and the much larger pore size vascular porosity in normal, cyclic, whole body motion (e.g., walking). The techniques for accomplishing these measurements have been explored in a pilot study. The development of a poroelastic model to predict the interchange of interstitial fluid between the lacunar-canalicular porosity and the much larger pore size vascular porosity in normal, cyclic, whole body motion introduces a new concept of nested pore space structures. Understanding bone mechanotransduction is fundamental to the understanding of how to treat osteoporosis, how to cope with microgravity in long term manned space flight and how to design prostheses that are implanted in bone tissue to function for longer periods. The research project will involve CCNY and City Tech students, students at the CCNY High School for Math, Science and Engineering as well as students at M.S. 319, the Maria Teresa Maribal School. The NYC professional community interested in bone health will be kept abreast of research developments in the public NYC Bone Seminar Series.