Feeding and exciting bone cells with interstitial fluid movement

在这个项目中，PI将测量腔隙-小管骨孔洞的渗透性，并将开发一个多孔弹性模型来预测在正常的、周期性的、全身运动(如行走)中，腔隙-小管孔和大得多的孔径的血管孔洞之间的间质流体的交换。完成这些测量的技术已经在一项初步研究中进行了探索。在正常的、周期性的、全身运动中，用来预测腔隙-管状孔隙度和大得多的孔洞大小的血管孔隙度之间的间隙流体交换的孔弹性模型的发展引入了嵌套孔隙空间结构的新概念。了解骨力学转导对于理解如何治疗骨质疏松症、如何应对长期载人航天中的微重力以及如何设计植入骨组织的假体以延长功能周期是至关重要的。该研究项目将涉及CCNY和City Tech的学生、CCNY数学、科学和工程高中的学生以及M.S.319玛丽亚·特蕾莎·马里巴尔学校的学生。对骨骼健康感兴趣的纽约市专业社区将与公共纽约市骨骼研讨会系列的研究进展保持同步。

In this project the PI will measure the permeability of the lacunar-canalicular bone porosity and will develop a poroelastic model to predict the interchange of interstitial fluid between the lacunar-canalicular porosity and the much larger pore size vascular porosity in normal, cyclic, whole body motion (e.g., walking). The techniques for accomplishing these measurements have been explored in a pilot study. The development of a poroelastic model to predict the interchange of interstitial fluid between the lacunar-canalicular porosity and the much larger pore size vascular porosity in normal, cyclic, whole body motion introduces a new concept of nested pore space structures. Understanding bone mechanotransduction is fundamental to the understanding of how to treat osteoporosis, how to cope with microgravity in long term manned space flight and how to design prostheses that are implanted in bone tissue to function for longer periods. The research project will involve CCNY and City Tech students, students at the CCNY High School for Math, Science and Engineering as well as students at M.S. 319, the Maria Teresa Maribal School. The NYC professional community interested in bone health will be kept abreast of research developments in the public NYC Bone Seminar Series.