Mechanisms Mediating the Control of Prolactin Secretion in the Teleost Fish

介导硬骨鱼催乳素分泌控制的机制

• 批准号: 9104494
• 负责人: E. Gordon Grau
• 金额: $ 16.93万
• 依托单位: University of Hawaii
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-07-15 至 1995-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9104494&HistoricalAwards=false
• 关键词: Mechanisms; Mediating; Control; Prolactin; Secretion

Prolactin (PRL) is a hormone which is very important in the regulation of salt and water balance, and in reproduction and in the stimulation of mammary growth and function. The pituitary of bony fishes is an attractive system for studying prolactin (PRL) secretion. Unique among vertebrate animals, teleost PRL cells are segregated as a nearly homogeneous mass which is easily separated for study in isolation from other body systems. Also, these PRL cells can be maintained in their normal cell-cell associations for at least two weeks in culture dishes. These features facilitate the achievement of the goals of this project which are to characterize PRL secretory mechanisms using normal (i.e. not cancerous) tissues. Studies will be directed toward the examination of several peptide and steroid hormones that may be important regulators of PRL cell function. These factors will be used to continue the characterization of the mechanisms that control PRL cells. Companion studies will examine the manner in which the PRL cell responds to osmotic pressure. These studies will help to clarify how the secretion of the hormones that control salt and water balance is regulated.//

催乳素 (PRL) 是一种在调节盐和水平衡、生殖以及刺激乳腺生长和功能方面非常重要的激素。 硬骨鱼的垂体是研究催乳素（PRL）分泌的一个有吸引力的系统。 硬骨鱼 PRL 细胞在脊椎动物中是独一无二的，它被分离成几乎均匀的团块，很容易与其他身体系统分离以进行研究。 此外，这些 PRL 细胞可以在培养皿中保持正常的细胞-细胞关联至少两周。 这些特征有助于实现该项目的目标，即使用正常（即非癌性）组织来表征 PRL 分泌机制。 研究将针对几种肽和类固醇激素的检查，这些激素可能是 PRL 细胞功能的重要调节剂。 这些因素将用于继续表征控制 PRL 细胞的机制。 配套研究将检查 PRL 细胞对渗透压的反应方式。 这些研究将有助于阐明控制盐和水平衡的激素的分泌是如何调节的。//