U.S.-Japan Cooperative Science: Studies on the Control and Actions of Prolactin in Teleost Fishes

9910115该奖项支持夏威夷大学马诺阿分校的戈登·格劳教授和日本广岛大学的安藤正明教授之间为期三年的合作研究项目。研究人员将对硬骨鱼中催乳素的控制和作用进行研究。催乳素(PRL)对电解质平衡、生长发育、生殖、新陈代谢、行为和免疫系统都有影响。FISH为研究催乳素的作用和控制催乳素的释放提供了很好的模型。从四种系统发育不同的鱼类中识别和鉴定催乳素释放肽(PRPS)是这项提议的科学目标。这将涉及：1)PRPS对盐度适应的影响；2)环境盐度对PRP mRNA表达和循环PRP和PRL水平的影响；3)PRPS与其他影响PRO释放的因素的相互作用；4)PRPS刺激PRL释放的机制(S)。将研究的四种鱼是罗非鱼、鲤鱼、鳗鱼和弹涂鱼。该项目汇集了两个拥有互补专业知识和研究能力的实验室的努力。实验结果将极大地促进对鱼类体内催乳素释放的了解，并为一般脊椎动物体内催乳素的释放提供洞察力。这项研究通过博士后和研究生的参与促进了国际人力资源的发展。通过思想和技术的交流，这个项目将扩大我们的基础知识基础，促进国际理解与合作。研究人员计划将研究结果发表在科学期刊上

9910115GrauThis award supports a three year collaborative research project between Professor Gordon Grau of the University of Hawaii at Manoa and Professor Masaaki Ando of Hiroshima University in Japan. The researchers will be undertaking a study on the control and actions of prolactin in teleost fishes. Prolactin (PRL) is known to have effects on electrolyte balance, growth and development, reproduction, metabolism, behavior, and the immune system. Fish present excellent models for the study of action of PRL and the control of PRL release. Identifying and characterizing prolactin-releasing peptides (PRPs) from four phylogenetically diverse fish species are the scientific goals of this proposal. This will involve: 1) the effect of PRPs on salinity adaptation; 2) the effect of environmental salinity on the expression of PRP mRNA and on circulating PRP and PRL levels; 3) the interaction of PRPs with other factors that influence PRO release; and 4) the mechanism(s) through which PRPs stimulate PRL release. The four fish to be studied are the tilapia, carp, eel and mudskipper.The project brings together the efforts of two laboratories that have complementary expertise and research capabilities. The results of the experiments should significantly advance the understanding of PRL release in fish and provide insights into PRL release in vertebrate species in general. This research advances international human resources through the participation of postdoc and graduate students. Through the exchange of ideas and technology, this project will broaden our base of basic knowledge and promote international understanding and cooperation. The researchers plan to publish results of the research in scientific journals