U.S.-Japan Planning Visit: Hormonal control of body fluid homeostasis in fish; Interactions between fast-acting and slow-acting hormones

OISE-0852518（格劳，夏威夷大学）？鱼类体液平衡的激素控制：快效激素和慢效激素之间的相互作用？摘要该奖项支持PI Grau和东京大学的Yoshio Takei教授之间的规划和早期合作研究活动，以进一步开发两种广盐性硬骨鱼，鳗鱼和罗非鱼的比较研究，以阐明面对环境盐度的巨大变化，渗透和离子调节中采用的共同机制。这些鱼是比较研究的理想模型，因为它们与包括人类在内的高等脊椎动物有许多共同的特征，这些特征涉及体液的稳态。参与鱼类适应性调节的激素可分为两类：快速作用的激素和缓慢但长效的激素。这两类激素之间的相互作用还不清楚。该提案的目标是：1）整合通常彼此不同和分离的科学探究领域，即，2）开展合作研究，以确定调节鳗鱼和罗非鱼相关内分泌系统活动的关键基因和蛋白质，以响应环境盐度的变化; 3）通过使青年科学家接触单一实验室无法提供的知识和培训的独特组合，开发新的方法、概念和方法，以及4）培养个人和专业关系，这些关系将延伸到拟议的工作之外。双方的年轻科学家，博士后研究员和研究生以及教师将参加minisymopsia和研讨会，并在竹井博士的短期培训经验？s实验室。

OISE-0852518 (Grau, University of Hawaii) ?Hormonal control of body fluid homeostasis in fish: Interactions between fast-acting hormones and slow-acting hormones?Abstract This award supports planning and early-stage collaborative research activities between PI Grau and Professor Yoshio Takei of the University of Tokyo to further develop comparative studies on two euryhaline teleosts, eel and tilapia, to elucidate shared mechanisms that are employed in osmotic and ionic regulation in the face of large changes in environmental salinity. These fishes are ideal models for comparative studies, since they share many features in common with higher vertebrates including humans that are involved in homeostasis of body fluids. Hormones involved in osmoregulatory adaptation in fish can be classified into two categories; fast-acting hormones and slow- but long-acting hormones. Interactions between the two categories of the hormones are not well understood. The goals of the proposal are to 1) integrate areas of scientific inquiry that are typically distinct and separate from one another, i.e., fast-acting hormones vs. long-lasting hormones, and eel vs. tilapia; 2) initiate collaborative research to identify key genes and proteins that regulate activities of relevant endocrine systems in both eel and tilapia in response to environmental changes in salinity; 3) develop new methods, concepts and approaches by exposing young scientists to a unique mixture of knowledge and training not available in a single laboratory, and 4) foster personal and professional relationships that will extend beyond the proposed work. Young scientists, postdoctoral fellows and graduate students, and faculty on both sides will participate in minisymposia and workshops as well as have short-term training experiences in Dr. Takei?s lab.