DNA Dynamics in Strongly Interacting Solutions

这项建议的目的是了解生物聚电解质，特别是DNA，在强相互作用溶液中的动力学行为。相互作用可以是静电、排除体积、纠缠或某种组合。这样的条件是细胞内的常态。这项工作使用准弹性光散射(QLS)、强迫瑞利散射(FRS)和小角X射线散射(SAXS)来阐明相互作用如何影响生物聚合物的扩散和结合行为。在生理相关的条件下，这种影响可能会产生重大影响。

The goal of this proposal is to understand the dynamical behavior of biological polyelectrolytes, especially DNA, in strongly interacting solutions. the interactions may be electrostatic, excluded volume, entanglement, or some combination. Such conditions are the norms inside cells. The work uses quasielastic light scattering (QLS), forced Rayleigh scattering (FRS), and small-angle x-ray scattering (SAXS) to shed light on how interactions influence the diffusional and binding behavior of biopolymers. Such influence can have major effects under physiologically relevant conditions.