Metal Complex Activation of Dioxygen

双氧的金属配合物活化

• 批准号: 9106545
• 负责人: Joan Valentine
• 金额: $ 40.3万
• 依托单位: University of California-Los Angeles
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-07-01 至 1995-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9106545&HistoricalAwards=false
• 关键词: Metal; Complex; Activation; Dioxygen

This award to Dr. Joan S. Valentine of the Chemistry Department, University of California at Los Angeles, is made by the Inorganic, Bioinorganic, and Organometallic Program. It supports work in three related areas: model intermediates for the reactions of non-heme monooxygenase enzymes; organic cofactors required by dioxygenase enzymes; and the synthesis and characterization of metalloporphyrin peroxo complexes of iron and chromium, which may model intermediates in the activation of dioxygen by heme-containing monooxygenase enzymes. In the first area, Dr. Valentine will study the role of Fe-cyclam and related complexes in olefin epoxidation reactions with hydrogen peroxide, alkyl hydroperoxides, and organic peracids. In the second study, benzolylformate complexes of iron and tetrahydropterin complexes of iron and cobalt will be synthesized and investigated. %%% The overall goal of the proposed research is to design catalysts for oxygenation reactions, and in the process better understand the mechanism of biological dioxygen and monooxygen activation.

这个奖项是由Joan S博士颁发的。化学情人节 系，加州大学洛杉矶分校，是由 无机，生物无机和有机物计划。 它 支持三个相关领域的工作： 非血红素单加氧酶的反应;有机 双加氧酶所需的辅因子;以及合成 金属卟啉过氧配合物的合成和表征 铁和铬，这可能是模型中的中间体， 含血红素单加氧酶激活双氧 内切酶 在第一个领域，瓦伦丁博士将研究 环拉胺铁配合物在烯烃环氧化反应中的应用 与过氧化氢、烷基氢过氧化物和 有机过酸 在第二项研究中， 铁和四氢蝶呤的络合物 钴将被合成和研究。 %%% 本研究的总体目标是设计 氧化反应的催化剂，在这个过程中， 了解生物双氧和单氧的机理 activation.